H3K36me3, message from chromatin to DNA damage repair
Abstract Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage. There are diverse clues showing H3K36me3 particip...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-01-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-020-0374-z |
| _version_ | 1818648062701076480 |
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| author | Zhongxing Sun Yanjun Zhang Junqi Jia Yuan Fang Yin Tang Hongfei Wu Dong Fang |
| author_facet | Zhongxing Sun Yanjun Zhang Junqi Jia Yuan Fang Yin Tang Hongfei Wu Dong Fang |
| author_sort | Zhongxing Sun |
| collection | DOAJ |
| description | Abstract Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage. There are diverse clues showing H3K36me3 participates in DNA damage response by directly recruiting DNA repair machinery to set the chromatin at a “ready” status, leading to a quick response upon damage. Reduced H3K36me3 is associated with low DNA repair efficiency. This review will also place a main emphasis on the H3K36me3-mediated DNA damage repair in the tumorigenesis of the newly found oncohistone mutant tumors. Gaining an understanding of different aspects of H3K36me3 in DNA damage repair, especially in cancers, would share the knowledge of chromatin and DNA repair to serve to the drug discovery and patient care. |
| first_indexed | 2024-12-17T01:12:27Z |
| format | Article |
| id | doaj.art-03e379bb1a1747da8c3c80d58dd13521 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-17T01:12:27Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-03e379bb1a1747da8c3c80d58dd135212022-12-21T22:09:06ZengBMCCell & Bioscience2045-37012020-01-011011910.1186/s13578-020-0374-zH3K36me3, message from chromatin to DNA damage repairZhongxing Sun0Yanjun Zhang1Junqi Jia2Yuan Fang3Yin Tang4Hongfei Wu5Dong Fang6Life Sciences Institute, Zhejiang UniversityLife Sciences Institute, Zhejiang UniversityLife Sciences Institute, Zhejiang UniversityLife Sciences Institute, Zhejiang UniversityLife Sciences Institute, Zhejiang UniversityLife Sciences Institute, Zhejiang UniversityLife Sciences Institute, Zhejiang UniversityAbstract Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage. There are diverse clues showing H3K36me3 participates in DNA damage response by directly recruiting DNA repair machinery to set the chromatin at a “ready” status, leading to a quick response upon damage. Reduced H3K36me3 is associated with low DNA repair efficiency. This review will also place a main emphasis on the H3K36me3-mediated DNA damage repair in the tumorigenesis of the newly found oncohistone mutant tumors. Gaining an understanding of different aspects of H3K36me3 in DNA damage repair, especially in cancers, would share the knowledge of chromatin and DNA repair to serve to the drug discovery and patient care.https://doi.org/10.1186/s13578-020-0374-zH3K36me3DNA damageOncohistonesHomologous recombinationNonhomologous end-joiningDNA mismatch repair |
| spellingShingle | Zhongxing Sun Yanjun Zhang Junqi Jia Yuan Fang Yin Tang Hongfei Wu Dong Fang H3K36me3, message from chromatin to DNA damage repair Cell & Bioscience H3K36me3 DNA damage Oncohistones Homologous recombination Nonhomologous end-joining DNA mismatch repair |
| title | H3K36me3, message from chromatin to DNA damage repair |
| title_full | H3K36me3, message from chromatin to DNA damage repair |
| title_fullStr | H3K36me3, message from chromatin to DNA damage repair |
| title_full_unstemmed | H3K36me3, message from chromatin to DNA damage repair |
| title_short | H3K36me3, message from chromatin to DNA damage repair |
| title_sort | h3k36me3 message from chromatin to dna damage repair |
| topic | H3K36me3 DNA damage Oncohistones Homologous recombination Nonhomologous end-joining DNA mismatch repair |
| url | https://doi.org/10.1186/s13578-020-0374-z |
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