Sulforaphane: An emergent anti-cancer stem cell agent
Cancer is a major public health concern worldwide responsible for high morbidity and mortality rates. Alternative therapies have been extensively investigated, and plant-derived compounds have caught the attention of the scientific community due to their chemopreventive and anticancer effects. Sulfo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1089115/full |
| _version_ | 1797942513914347520 |
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| author | Leandro de Lima Coutinho Tharcísio Citrangulo Tortelli Junior Maria Cristina Rangel |
| author_facet | Leandro de Lima Coutinho Tharcísio Citrangulo Tortelli Junior Maria Cristina Rangel |
| author_sort | Leandro de Lima Coutinho |
| collection | DOAJ |
| description | Cancer is a major public health concern worldwide responsible for high morbidity and mortality rates. Alternative therapies have been extensively investigated, and plant-derived compounds have caught the attention of the scientific community due to their chemopreventive and anticancer effects. Sulforaphane (SFN) is one of these naturally occurring agents, and studies have shown that it is able to target a specific cancer cell population displaying stem-like properties, known as cancer stem cells (CSCs). These cells can self-renewal and differentiate to form highly heterogeneous tumor masses. Notably, most of the conventional chemotherapeutic agents cannot target CSCs once they usually exist in a quiescent state and overall, the available cytotoxic drugs focus on highly dividing cells. This is, at least in part, one of the reasons why some oncologic patients relapse after standard therapy. In this review we bring together studies supporting not only the chemopreventive and anticancer properties of SFN, but especially the emerging anti-CSCs effects of this natural product and its potential to be used with conventional antineoplastic drugs in the clinical setting. |
| first_indexed | 2024-04-10T20:09:45Z |
| format | Article |
| id | doaj.art-03e3885dd6e443e38c97383a7b3f18b8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T20:09:45Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-03e3885dd6e443e38c97383a7b3f18b82023-01-26T13:51:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011310.3389/fonc.2023.10891151089115Sulforaphane: An emergent anti-cancer stem cell agentLeandro de Lima CoutinhoTharcísio Citrangulo Tortelli JuniorMaria Cristina RangelCancer is a major public health concern worldwide responsible for high morbidity and mortality rates. Alternative therapies have been extensively investigated, and plant-derived compounds have caught the attention of the scientific community due to their chemopreventive and anticancer effects. Sulforaphane (SFN) is one of these naturally occurring agents, and studies have shown that it is able to target a specific cancer cell population displaying stem-like properties, known as cancer stem cells (CSCs). These cells can self-renewal and differentiate to form highly heterogeneous tumor masses. Notably, most of the conventional chemotherapeutic agents cannot target CSCs once they usually exist in a quiescent state and overall, the available cytotoxic drugs focus on highly dividing cells. This is, at least in part, one of the reasons why some oncologic patients relapse after standard therapy. In this review we bring together studies supporting not only the chemopreventive and anticancer properties of SFN, but especially the emerging anti-CSCs effects of this natural product and its potential to be used with conventional antineoplastic drugs in the clinical setting.https://www.frontiersin.org/articles/10.3389/fonc.2023.1089115/fullnatural productsconventional therapycancer stem cellschemopreventionanticancer |
| spellingShingle | Leandro de Lima Coutinho Tharcísio Citrangulo Tortelli Junior Maria Cristina Rangel Sulforaphane: An emergent anti-cancer stem cell agent Frontiers in Oncology natural products conventional therapy cancer stem cells chemoprevention anticancer |
| title | Sulforaphane: An emergent anti-cancer stem cell agent |
| title_full | Sulforaphane: An emergent anti-cancer stem cell agent |
| title_fullStr | Sulforaphane: An emergent anti-cancer stem cell agent |
| title_full_unstemmed | Sulforaphane: An emergent anti-cancer stem cell agent |
| title_short | Sulforaphane: An emergent anti-cancer stem cell agent |
| title_sort | sulforaphane an emergent anti cancer stem cell agent |
| topic | natural products conventional therapy cancer stem cells chemoprevention anticancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1089115/full |
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