A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India
Background: Hepatitis B virus (HBV), hepatitis C virus (HCV), and Human immunodeficiency virus (HIV) infections are prevalent throughout the world. HIV infection increases the risk of HBV and HCV liver disease especially when HIV-associated immunodeficiency progresses. Aims and Objectives: This s...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-04-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/50299 |
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| author | Riddhi Pradhan Kirti Hemwani Vidit Khandelwal Bamboriya BL Yogyata Marothi Varsha Saxena |
| author_facet | Riddhi Pradhan Kirti Hemwani Vidit Khandelwal Bamboriya BL Yogyata Marothi Varsha Saxena |
| author_sort | Riddhi Pradhan |
| collection | DOAJ |
| description | Background: Hepatitis B virus (HBV), hepatitis C virus (HCV), and Human immunodeficiency virus (HIV) infections are prevalent throughout the world. HIV infection increases the risk of HBV and HCV liver disease especially when HIV-associated immunodeficiency progresses.
Aims and Objectives: This study was carried out with the objectives as follows: Estimation of the prevalence of HIV- Hepatitis co-infection, determine CD4+T lymphocyte count in co-infected patients, identify most common opportunistic infections in HIV – Hepatitis co- infection.
Materials and Methods: A hospital-based, prospective, cross-sectional, and observational study was carried among people with confirmed HIV infection. HIV antibody, hepatitis B surface antigen (HBsAg), and HCV antibody tests were done in all patients visiting to integrated counseling and testing center. HIV, HBV, and HCV viral load were done in all serologically confirmed patients. In HBsAg positive patients various markers for hepatitis such as hepatitis B envelop antigen (HBeAg), anti-hepatitis B core antibody (HBcAb), and anti-hepatitis B envelop antibody were also done.
Results: Out of 357 people living with HIV/AIDS (PLHA) patients 15/357 (4.20%) were co-infected with HBV, 03/357 (0.84%) were co-infected with HCV. The overall seroprevalence of Hepatitis virus (HBV+HCV) in PLHA patients was found to be 5.04% (18/357). CD4+T lymphocyte count <200 cells/μL was seen in 66/339 (19.4%), 04/15 (26.6%), and 03/03 (100%) patients of HIV mono-infected, HBV co-infected, and in HCV co-infected patients, respectively. HIV Viral load ≤1000 copies/mL was seen in 324 and 15 patients in HIV mono-infected and HIV- hepatitis co-infected patient, respectively. Among PLHA patients who were positive for HBsAg; 46.7% (n=7) patients had HBV viral load >2000 IU/mL. All hepatitis B co-infected patients were positive for HBcAb test; HBeAg was positive in 40% (n=06). All HBeAg positive were having viral load >2000 IU/mL.
Conclusion: HIV-infected patients are more prone to hepatitis associated liver diseases and exposure to the HBV infection than the general population. |
| first_indexed | 2024-04-09T20:06:03Z |
| format | Article |
| id | doaj.art-03e59af2dee146c4892b8f3ac5ed2ca4 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-09T20:06:03Z |
| publishDate | 2023-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-03e59af2dee146c4892b8f3ac5ed2ca42023-04-01T15:17:37ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-04-011446167https://doi.org/10.3126/ajms.v14i4.50299A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central IndiaRiddhi Pradhan 0https://orcid.org/0000-0003-1848-2370Kirti Hemwani 1https://orcid.org/0000-0001-9885-0836Vidit Khandelwal 2https://orcid.org/0000-0003-4161-6381Bamboriya BL 3https://orcid.org/0000-0002-3602-2995Yogyata Marothi 4https://orcid.org/0000-0002-6783-7871Varsha Saxena 5https://orcid.org/0000-0001-6457-4298Associate Professor, Department of Microbiology, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, India Associate Professor, Department of Microbiology, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, India Associate Professor, Department of Community Medicine, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, IndiaProfessor, Department of Medicine, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, India Professor and Head, Department of Microbiology, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, India Demonstrator, Department of Microbiology, 3Associate Professor, Department of Community Medicine, 4Professor, Department of Medicine, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, India Background: Hepatitis B virus (HBV), hepatitis C virus (HCV), and Human immunodeficiency virus (HIV) infections are prevalent throughout the world. HIV infection increases the risk of HBV and HCV liver disease especially when HIV-associated immunodeficiency progresses. Aims and Objectives: This study was carried out with the objectives as follows: Estimation of the prevalence of HIV- Hepatitis co-infection, determine CD4+T lymphocyte count in co-infected patients, identify most common opportunistic infections in HIV – Hepatitis co- infection. Materials and Methods: A hospital-based, prospective, cross-sectional, and observational study was carried among people with confirmed HIV infection. HIV antibody, hepatitis B surface antigen (HBsAg), and HCV antibody tests were done in all patients visiting to integrated counseling and testing center. HIV, HBV, and HCV viral load were done in all serologically confirmed patients. In HBsAg positive patients various markers for hepatitis such as hepatitis B envelop antigen (HBeAg), anti-hepatitis B core antibody (HBcAb), and anti-hepatitis B envelop antibody were also done. Results: Out of 357 people living with HIV/AIDS (PLHA) patients 15/357 (4.20%) were co-infected with HBV, 03/357 (0.84%) were co-infected with HCV. The overall seroprevalence of Hepatitis virus (HBV+HCV) in PLHA patients was found to be 5.04% (18/357). CD4+T lymphocyte count <200 cells/μL was seen in 66/339 (19.4%), 04/15 (26.6%), and 03/03 (100%) patients of HIV mono-infected, HBV co-infected, and in HCV co-infected patients, respectively. HIV Viral load ≤1000 copies/mL was seen in 324 and 15 patients in HIV mono-infected and HIV- hepatitis co-infected patient, respectively. Among PLHA patients who were positive for HBsAg; 46.7% (n=7) patients had HBV viral load >2000 IU/mL. All hepatitis B co-infected patients were positive for HBcAb test; HBeAg was positive in 40% (n=06). All HBeAg positive were having viral load >2000 IU/mL. Conclusion: HIV-infected patients are more prone to hepatitis associated liver diseases and exposure to the HBV infection than the general population.https://www.nepjol.info/index.php/AJMS/article/view/50299people living with hiv/aids; cd4 count; hiv-hepatitis virus co-infection; hiv-hbv and tb coinfection; viral load |
| spellingShingle | Riddhi Pradhan Kirti Hemwani Vidit Khandelwal Bamboriya BL Yogyata Marothi Varsha Saxena A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India Asian Journal of Medical Sciences people living with hiv/aids; cd4 count; hiv-hepatitis virus co-infection; hiv-hbv and tb coinfection; viral load |
| title | A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India |
| title_full | A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India |
| title_fullStr | A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India |
| title_full_unstemmed | A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India |
| title_short | A cross-sectional study on co-infection of hepatitis B and hepatitis C among people living with HIV/AIDS from a tertiary care hospital of Central India |
| title_sort | cross sectional study on co infection of hepatitis b and hepatitis c among people living with hiv aids from a tertiary care hospital of central india |
| topic | people living with hiv/aids; cd4 count; hiv-hepatitis virus co-infection; hiv-hbv and tb coinfection; viral load |
| url | https://www.nepjol.info/index.php/AJMS/article/view/50299 |
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