Ambient particulate matter associates with asthma in high altitude region: A population-based study
Background: Exposure to particulate matter (PM) has been a major public health threat, but the potentially differential effects on asthma of PM remain largely unknown in high altitude settings. We evaluated the effects of ambient PM on asthma in high altitude settings. Methods: The study recruited a...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455123000340 |
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| author | ZhenZhen Xing, MD Ting Yang, MD, PhD Su Shi, MD Xia Meng, MD Renjie Chen, MD, PhD Huanyu Long, MD Yanlu Hu, MD Di Chai, MD WeiMing Liu, MD YaQi Tong, MD YuXia Wang, MD YaLi Ma, MD MingMing Pan, MD Jia Cui, MD TieYing Sun, MD, PhD YanFei Guo, MD, PhD |
| author_facet | ZhenZhen Xing, MD Ting Yang, MD, PhD Su Shi, MD Xia Meng, MD Renjie Chen, MD, PhD Huanyu Long, MD Yanlu Hu, MD Di Chai, MD WeiMing Liu, MD YaQi Tong, MD YuXia Wang, MD YaLi Ma, MD MingMing Pan, MD Jia Cui, MD TieYing Sun, MD, PhD YanFei Guo, MD, PhD |
| author_sort | ZhenZhen Xing, MD |
| collection | DOAJ |
| description | Background: Exposure to particulate matter (PM) has been a major public health threat, but the potentially differential effects on asthma of PM remain largely unknown in high altitude settings. We evaluated the effects of ambient PM on asthma in high altitude settings. Methods: The study recruited a representative sample from high altitude settings using a multistage stratified sampling procedure. Asthma was defined by a self-reported history of diagnosis by a physician or by wheezing symptoms in the preceding 12 months. The annual mean PM2.5 and PM10 concentrations were calculated for each grid cell at 1-km spatial resolution based on the geographical coordinates. Results: We analyzed data for participants (mean age 39.1 years, 51.4% female) and 183 (3.7%, 95% confidence interval (CI): 3.2–4.2) of the participants had asthma. Prevalence was higher in women (4.3%, 95% CI 3.5–5.1) than in men (3.1%, 2.4–3.8) and increasing with higher concentration of PM exposures. For an interquartile range (IQR) difference (8.77 μg/m3) in PM2.5 exposure, the adjusted odds ratio (OR) was 1.64 (95% CI 1.46–1.83, P < 0.001) for risk of asthma. For PM10, there was evidence for an association with risk of asthma (OR 2.34, 95% CI: 1.75–3.15, P < 0.001 per IQR of 43.26 μg/m3). Further analyses showed that household mold or damp exposure may aggravate PM exposure associated risks of asthma. Conclusions: This study identified that PM exposure could be a dominate environmental risk factor for asthma but largely unconsidered in the high-altitude areas. The association between PM exposure and asthma should be of interest for planners of national policies and encourage programs for prevention of asthma in residents living at high altitudes. |
| first_indexed | 2024-03-13T06:16:13Z |
| format | Article |
| id | doaj.art-03e7d8b8816c42ad97494a26752d90d9 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-03-13T06:16:13Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-03e7d8b8816c42ad97494a26752d90d92023-06-11T04:14:19ZengElsevierWorld Allergy Organization Journal1939-45512023-05-01165100774Ambient particulate matter associates with asthma in high altitude region: A population-based studyZhenZhen Xing, MD0Ting Yang, MD, PhD1Su Shi, MD2Xia Meng, MD3Renjie Chen, MD, PhD4Huanyu Long, MD5Yanlu Hu, MD6Di Chai, MD7WeiMing Liu, MD8YaQi Tong, MD9YuXia Wang, MD10YaLi Ma, MD11MingMing Pan, MD12Jia Cui, MD13TieYing Sun, MD, PhD14YanFei Guo, MD, PhD15Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, China; National Center for Respiratory Medicine & National Clinical Research Center for Respiratory Diseases, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, China; Department of Respiratory Medicine, Capital Medical University, Beijing, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Intensive Care Medicine, Beijing Boai Hospital, Rehabilitation Research Center, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaPeking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Corresponding author. No.1 DaHua Road, Dong Dan, Beijing 100730, China.Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Corresponding author. No.1 DaHua Road, Dong Dan, Beijing 100730, China.Background: Exposure to particulate matter (PM) has been a major public health threat, but the potentially differential effects on asthma of PM remain largely unknown in high altitude settings. We evaluated the effects of ambient PM on asthma in high altitude settings. Methods: The study recruited a representative sample from high altitude settings using a multistage stratified sampling procedure. Asthma was defined by a self-reported history of diagnosis by a physician or by wheezing symptoms in the preceding 12 months. The annual mean PM2.5 and PM10 concentrations were calculated for each grid cell at 1-km spatial resolution based on the geographical coordinates. Results: We analyzed data for participants (mean age 39.1 years, 51.4% female) and 183 (3.7%, 95% confidence interval (CI): 3.2–4.2) of the participants had asthma. Prevalence was higher in women (4.3%, 95% CI 3.5–5.1) than in men (3.1%, 2.4–3.8) and increasing with higher concentration of PM exposures. For an interquartile range (IQR) difference (8.77 μg/m3) in PM2.5 exposure, the adjusted odds ratio (OR) was 1.64 (95% CI 1.46–1.83, P < 0.001) for risk of asthma. For PM10, there was evidence for an association with risk of asthma (OR 2.34, 95% CI: 1.75–3.15, P < 0.001 per IQR of 43.26 μg/m3). Further analyses showed that household mold or damp exposure may aggravate PM exposure associated risks of asthma. Conclusions: This study identified that PM exposure could be a dominate environmental risk factor for asthma but largely unconsidered in the high-altitude areas. The association between PM exposure and asthma should be of interest for planners of national policies and encourage programs for prevention of asthma in residents living at high altitudes.http://www.sciencedirect.com/science/article/pii/S1939455123000340AsthmaAir pollutionHigh altitudeParticulate matterLow- and middle-income region |
| spellingShingle | ZhenZhen Xing, MD Ting Yang, MD, PhD Su Shi, MD Xia Meng, MD Renjie Chen, MD, PhD Huanyu Long, MD Yanlu Hu, MD Di Chai, MD WeiMing Liu, MD YaQi Tong, MD YuXia Wang, MD YaLi Ma, MD MingMing Pan, MD Jia Cui, MD TieYing Sun, MD, PhD YanFei Guo, MD, PhD Ambient particulate matter associates with asthma in high altitude region: A population-based study World Allergy Organization Journal Asthma Air pollution High altitude Particulate matter Low- and middle-income region |
| title | Ambient particulate matter associates with asthma in high altitude region: A population-based study |
| title_full | Ambient particulate matter associates with asthma in high altitude region: A population-based study |
| title_fullStr | Ambient particulate matter associates with asthma in high altitude region: A population-based study |
| title_full_unstemmed | Ambient particulate matter associates with asthma in high altitude region: A population-based study |
| title_short | Ambient particulate matter associates with asthma in high altitude region: A population-based study |
| title_sort | ambient particulate matter associates with asthma in high altitude region a population based study |
| topic | Asthma Air pollution High altitude Particulate matter Low- and middle-income region |
| url | http://www.sciencedirect.com/science/article/pii/S1939455123000340 |
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