COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination
ObjectiveTo determine the reasons why pulmonary hypertension (PH) children refused vaccination against COVID-19, evaluate the safety and efficacy of COVID-19 vaccine in PH children.Study designThis retrospective cohort study included congenital heart disease-associated pulmonary arterial hypertensio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1259753/full |
| _version_ | 1797666486146301952 |
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| author | Zeying Zhang Dan Wang Wanyun Zuo Xun Wang Fan Yang Haiyan Luo Zhenghui Xiao Qiming Liu Yunbin Xiao |
| author_facet | Zeying Zhang Dan Wang Wanyun Zuo Xun Wang Fan Yang Haiyan Luo Zhenghui Xiao Qiming Liu Yunbin Xiao |
| author_sort | Zeying Zhang |
| collection | DOAJ |
| description | ObjectiveTo determine the reasons why pulmonary hypertension (PH) children refused vaccination against COVID-19, evaluate the safety and efficacy of COVID-19 vaccine in PH children.Study designThis retrospective cohort study included congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH) and bronchopulmonary dysplasia associated PH (BPD-PH) children who were divided into vaccinated group and non-vaccinated group. Univariate logistic regression analysis and multivariate logistic regression analysis were conducted to explore the reasons why PH children refused COVID-19 vaccine. Then, the prevalence, the number of symptoms, and the severity of COVID-19 disease were compared between the vaccinated and unvaccinated groups.ResultWe included 73 children and 61 children (83.6%) were unvaccinated. The main reasons for not being vaccinated were fear of worsening of existing diseases (31%). Age < 36 months (RR: 0.012; P < 0.001) and the presence of comorbidities (RR = 0.06; P = 0.023) were risk factors influencing willingness to vaccinate. The most common adverse events (AEs) were injection site pain (29.6%). COVID-19 vaccines are safe for PH children. The prevalence of COVID-19 disease decreased in PH children after vaccination (RR = 0.51; P = 0.009). 1 month after negative nucleic acid test or negative antigen test, PH children in the vaccinated group had fewer symptoms (P = 0.049).ConclusionsThe vaccination rate of COVID-19 vaccine is low in CHD-PAH and BPD-PH children while COVID-19 vaccines are safe. Vaccination can reduce the prevalence of COVID-19 disease and the number of symptoms 1 month after negative nucleic acid or antigen tests. |
| first_indexed | 2024-03-11T19:59:04Z |
| format | Article |
| id | doaj.art-03ebd479db39414c9ae02146dfdc14f4 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T19:59:04Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-03ebd479db39414c9ae02146dfdc14f42023-10-04T09:43:40ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-10-011110.3389/fped.2023.12597531259753COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccinationZeying Zhang0Dan Wang1Wanyun Zuo2Xun Wang3Fan Yang4Haiyan Luo5Zhenghui Xiao6Qiming Liu7Yunbin Xiao8Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, Hunan Children’s Hospital, Changsha, ChinaDepartment of Hematology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, Hunan Children’s Hospital, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, Hunan Children’s Hospital, Changsha, ChinaDepartment of Cardiology, Hunan Children’s Hospital, Changsha, ChinaDepartment of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiology, Hunan Children’s Hospital, Changsha, ChinaObjectiveTo determine the reasons why pulmonary hypertension (PH) children refused vaccination against COVID-19, evaluate the safety and efficacy of COVID-19 vaccine in PH children.Study designThis retrospective cohort study included congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH) and bronchopulmonary dysplasia associated PH (BPD-PH) children who were divided into vaccinated group and non-vaccinated group. Univariate logistic regression analysis and multivariate logistic regression analysis were conducted to explore the reasons why PH children refused COVID-19 vaccine. Then, the prevalence, the number of symptoms, and the severity of COVID-19 disease were compared between the vaccinated and unvaccinated groups.ResultWe included 73 children and 61 children (83.6%) were unvaccinated. The main reasons for not being vaccinated were fear of worsening of existing diseases (31%). Age < 36 months (RR: 0.012; P < 0.001) and the presence of comorbidities (RR = 0.06; P = 0.023) were risk factors influencing willingness to vaccinate. The most common adverse events (AEs) were injection site pain (29.6%). COVID-19 vaccines are safe for PH children. The prevalence of COVID-19 disease decreased in PH children after vaccination (RR = 0.51; P = 0.009). 1 month after negative nucleic acid test or negative antigen test, PH children in the vaccinated group had fewer symptoms (P = 0.049).ConclusionsThe vaccination rate of COVID-19 vaccine is low in CHD-PAH and BPD-PH children while COVID-19 vaccines are safe. Vaccination can reduce the prevalence of COVID-19 disease and the number of symptoms 1 month after negative nucleic acid or antigen tests.https://www.frontiersin.org/articles/10.3389/fped.2023.1259753/fullpulmonary hypertensionCOVID-19vaccinationhesitationadverse effects |
| spellingShingle | Zeying Zhang Dan Wang Wanyun Zuo Xun Wang Fan Yang Haiyan Luo Zhenghui Xiao Qiming Liu Yunbin Xiao COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination Frontiers in Pediatrics pulmonary hypertension COVID-19 vaccination hesitation adverse effects |
| title | COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination |
| title_full | COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination |
| title_fullStr | COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination |
| title_full_unstemmed | COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination |
| title_short | COVID-19 vaccination for children with pulmonary hypertension: efficacy, safety and reasons for opting against vaccination |
| title_sort | covid 19 vaccination for children with pulmonary hypertension efficacy safety and reasons for opting against vaccination |
| topic | pulmonary hypertension COVID-19 vaccination hesitation adverse effects |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1259753/full |
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