A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525
For the benefit of antibacterial Ti on orthopedic and dental implants, a bioactive coating (Pac@PLGA MS/HA coated Ti) was deposited on the surface of pure titanium (Ti), which included two layers: an acid–alkali heat pretreated biomimetic mineralization layer and an electrosprayed Poly (D,L-lactide-...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/11/12/3306 |
| _version_ | 1797501959366770688 |
|---|---|
| author | Yuzhu He Yuanyuan Li Enjun Zuo Songling Chai Xiang Ren Tao Fei Guowu Ma Xiumei Wang Huiying Liu |
| author_facet | Yuzhu He Yuanyuan Li Enjun Zuo Songling Chai Xiang Ren Tao Fei Guowu Ma Xiumei Wang Huiying Liu |
| author_sort | Yuzhu He |
| collection | DOAJ |
| description | For the benefit of antibacterial Ti on orthopedic and dental implants, a bioactive coating (Pac@PLGA MS/HA coated Ti) was deposited on the surface of pure titanium (Ti), which included two layers: an acid–alkali heat pretreated biomimetic mineralization layer and an electrosprayed Poly (D,L-lactide-co- glycolic acid) (PLGA) microsphere layer as a sustained-release system. Hydroxyapatite (HA) in mineralization layer was primarily prepared on the Ti followed by the antibacterial coating of Pac-525 loaded by PLGA microspheres. After observing the antimicrobial peptides distributed uniformly on the titanium surface, the release assay showed that the release of Pac-525 from Pac@PLGA MS/HA coated Ti provided a large initial burst followed by a slow release at a flat rate. Pac@PLGA MS/HA coated Ti exhibited a strong cytotoxicity to both Gram-negative bacteria (<i>Escherichia coli</i>) and Gram-positive bacteria (<i>Staphylococcus aureus</i>). In addition, Pac@PLGA MS/HA coated Ti did not affect the growth and adhesion of the osteoblast-like cell line, MC3T3-E1. These data suggested that a bionic mineralized composite coating with long-term antimicrobial activity was successfully prepared. |
| first_indexed | 2024-03-10T03:25:58Z |
| format | Article |
| id | doaj.art-03ec3b89ce384ea9b434df93983857bf |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:25:58Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-03ec3b89ce384ea9b434df93983857bf2023-11-23T09:50:46ZengMDPI AGNanomaterials2079-49912021-12-011112330610.3390/nano11123306A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525Yuzhu He0Yuanyuan Li1Enjun Zuo2Songling Chai3Xiang Ren4Tao Fei5Guowu Ma6Xiumei Wang7Huiying Liu8School of Stomatology, Dalian Medical University, Dalian 116044, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaSchool of Stomatology, Dalian Medical University, Dalian 116044, ChinaFor the benefit of antibacterial Ti on orthopedic and dental implants, a bioactive coating (Pac@PLGA MS/HA coated Ti) was deposited on the surface of pure titanium (Ti), which included two layers: an acid–alkali heat pretreated biomimetic mineralization layer and an electrosprayed Poly (D,L-lactide-co- glycolic acid) (PLGA) microsphere layer as a sustained-release system. Hydroxyapatite (HA) in mineralization layer was primarily prepared on the Ti followed by the antibacterial coating of Pac-525 loaded by PLGA microspheres. After observing the antimicrobial peptides distributed uniformly on the titanium surface, the release assay showed that the release of Pac-525 from Pac@PLGA MS/HA coated Ti provided a large initial burst followed by a slow release at a flat rate. Pac@PLGA MS/HA coated Ti exhibited a strong cytotoxicity to both Gram-negative bacteria (<i>Escherichia coli</i>) and Gram-positive bacteria (<i>Staphylococcus aureus</i>). In addition, Pac@PLGA MS/HA coated Ti did not affect the growth and adhesion of the osteoblast-like cell line, MC3T3-E1. These data suggested that a bionic mineralized composite coating with long-term antimicrobial activity was successfully prepared.https://www.mdpi.com/2079-4991/11/12/3306titanium modificationelectrosprayacid–alkali heat pretreated mineralizationPac-525 |
| spellingShingle | Yuzhu He Yuanyuan Li Enjun Zuo Songling Chai Xiang Ren Tao Fei Guowu Ma Xiumei Wang Huiying Liu A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525 Nanomaterials titanium modification electrospray acid–alkali heat pretreated mineralization Pac-525 |
| title | A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525 |
| title_full | A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525 |
| title_fullStr | A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525 |
| title_full_unstemmed | A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525 |
| title_short | A Novel Antibacterial Titanium Modification with a Sustained Release of Pac-525 |
| title_sort | novel antibacterial titanium modification with a sustained release of pac 525 |
| topic | titanium modification electrospray acid–alkali heat pretreated mineralization Pac-525 |
| url | https://www.mdpi.com/2079-4991/11/12/3306 |
| work_keys_str_mv | AT yuzhuhe anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT yuanyuanli anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT enjunzuo anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT songlingchai anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT xiangren anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT taofei anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT guowuma anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT xiumeiwang anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT huiyingliu anovelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT yuzhuhe novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT yuanyuanli novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT enjunzuo novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT songlingchai novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT xiangren novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT taofei novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT guowuma novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT xiumeiwang novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 AT huiyingliu novelantibacterialtitaniummodificationwithasustainedreleaseofpac525 |