Colorectal Cancer: Prognostic Values
After lung cancer colorectal cancer (Cc) is ranked the second, as a cause of cancer-related death. The purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor bor...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2009-02-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2851 |
| _version_ | 1797260799495897088 |
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| author | Suzana Manxhuka-Kerliu Skender Telaku Halil Ahmetaj Arijeta Baruti Sadushe Loxha Agron Kerliu |
| author_facet | Suzana Manxhuka-Kerliu Skender Telaku Halil Ahmetaj Arijeta Baruti Sadushe Loxha Agron Kerliu |
| author_sort | Suzana Manxhuka-Kerliu |
| collection | DOAJ |
| description |
After lung cancer colorectal cancer (Cc) is ranked the second, as a cause of cancer-related death. The purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor border features. There were investigated 149 cases of resection specimen with colorectal cancer, which were fixed in buffered neutral formalin and embedded in paraffin. Tissue sections (4(µm thick) were cut and stained with H&E. Adenocarcinoma was the most frequent histological type found in 85,90% of cases, in 60,94% of males and 39,06% of females; squamous cell carcinoma in 7,38%, in 63,63% of males and 36,36% of females; mucinous carcinoma in 4,68%, in 57,15% of males and 42,85% of females; while adenosquamous carcinoma, undifferentiated carcinoma and carcinoma in situ in 0,71% of cases each. Dukes' classification was used in order to define the depth of invasion. Dukes B was found in 68,45% of cases, whereas in 31,54% of cases Dukes C was found. As far as histological grading is concerned, Cc was mostly with moderate differentiation (75,16%) with neither vascular nor perineural invasion. Resection margins were in all cases free of tumor. Our data indicate that the pathologic features of the resection specimen constitute the most powerful predictors of postoperative outcome in Cc. Dukes' stage and degree of differentiation provide independent prognostic information in Cc. However, differentiation should be assessed by the worst pattern.
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| first_indexed | 2024-04-24T23:31:04Z |
| format | Article |
| id | doaj.art-03eeb6b0a0484b1eabb8752664eb223c |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:04Z |
| publishDate | 2009-02-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-03eeb6b0a0484b1eabb8752664eb223c2024-03-15T14:37:00ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2009-02-019110.17305/bjbms.2009.2851513Colorectal Cancer: Prognostic ValuesSuzana Manxhuka-Kerliu0Skender Telaku1Halil Ahmetaj2Arijeta Baruti3Sadushe Loxha4Agron Kerliu5Institute of Pathology, Faculty of Medicine, University of PrishtinaGastroenterology Clinic, Faculty of Medicine, University of PrishtinaInstitute of Pathophysiology, Faculty of Medicine, University of PrishtinaInstitute of Pathology, Faculty of Medicine, University of PrishtinaInstitute of Pathology, Faculty of Medicine, University of PrishtinaInstitute of Pathophysiology, Faculty of Medicine, University of Prishtina After lung cancer colorectal cancer (Cc) is ranked the second, as a cause of cancer-related death. The purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor border features. There were investigated 149 cases of resection specimen with colorectal cancer, which were fixed in buffered neutral formalin and embedded in paraffin. Tissue sections (4(µm thick) were cut and stained with H&E. Adenocarcinoma was the most frequent histological type found in 85,90% of cases, in 60,94% of males and 39,06% of females; squamous cell carcinoma in 7,38%, in 63,63% of males and 36,36% of females; mucinous carcinoma in 4,68%, in 57,15% of males and 42,85% of females; while adenosquamous carcinoma, undifferentiated carcinoma and carcinoma in situ in 0,71% of cases each. Dukes' classification was used in order to define the depth of invasion. Dukes B was found in 68,45% of cases, whereas in 31,54% of cases Dukes C was found. As far as histological grading is concerned, Cc was mostly with moderate differentiation (75,16%) with neither vascular nor perineural invasion. Resection margins were in all cases free of tumor. Our data indicate that the pathologic features of the resection specimen constitute the most powerful predictors of postoperative outcome in Cc. Dukes' stage and degree of differentiation provide independent prognostic information in Cc. However, differentiation should be assessed by the worst pattern. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2851circumferential margincolon cancergradepathologyprognostic factorsDukes’ system |
| spellingShingle | Suzana Manxhuka-Kerliu Skender Telaku Halil Ahmetaj Arijeta Baruti Sadushe Loxha Agron Kerliu Colorectal Cancer: Prognostic Values Biomolecules & Biomedicine circumferential margin colon cancer grade pathology prognostic factors Dukes’ system |
| title | Colorectal Cancer: Prognostic Values |
| title_full | Colorectal Cancer: Prognostic Values |
| title_fullStr | Colorectal Cancer: Prognostic Values |
| title_full_unstemmed | Colorectal Cancer: Prognostic Values |
| title_short | Colorectal Cancer: Prognostic Values |
| title_sort | colorectal cancer prognostic values |
| topic | circumferential margin colon cancer grade pathology prognostic factors Dukes’ system |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2851 |
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