Chronic Periodontal Infection and Not Iatrogenic Interference Is the Trigger of Medication-Related Osteonecrosis of the Jaw: Insights from a Large Animal Study (PerioBRONJ Pig Model)

Chronic Periodontal Infection and Not Iatrogenic Interference Is the Trigger of Medication-Related Osteonecrosis of the Jaw: Insights from a Large Animal Study (PerioBRONJ Pig Model)

<i>Background and Objectives</i>: Antiresorptive drugs are widely used in osteology and oncology. An important adverse effect of these drugs is medication-induced osteonecrosis of the jaw (MRONJ). There is scientific uncertainty about the underlying pathomechanism of MRONJ. A promising t...

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Bibliographic Details
Main Authors: Matthias Troeltzsch, Stephan Zeiter, Daniel Arens, Dirk Nehrbass, Florian A. Probst, Paris Liokatis, Michael Ehrenfeld, Sven Otto
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Medicina
Subjects:
periodontitis
MRONJ
minipig animal model
chronic inflammation
osteonecrosis
periodontitis induction
Online Access:https://www.mdpi.com/1648-9144/59/5/1000

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