Age-related differences and sexual dimorphism in canine sleep spindles
Abstract Non-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-46434-y |
| _version_ | 1818997751020519424 |
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| author | Ivaylo Borislavov Iotchev Anna Kis Borbála Turcsán Daniel Rodrigo Tejeda Fernández de Lara Vivien Reicher Enikő Kubinyi |
| author_facet | Ivaylo Borislavov Iotchev Anna Kis Borbála Turcsán Daniel Rodrigo Tejeda Fernández de Lara Vivien Reicher Enikő Kubinyi |
| author_sort | Ivaylo Borislavov Iotchev |
| collection | DOAJ |
| description | Abstract Non-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investigated a large sample (N = 155) of intact and neutered pet dogs of both sexes, varying in breed and age, searching for spindles in segments of non-REM sleep. We recorded EEG from both a frontal midline electrode (Fz) and a central midline electrode (Cz) in 55.5% of the dogs, in the remaining animals only the Fz electrode was active (bipolar derivation). A similar topography was observed for fast (≥13 Hz) spindle occurrence as in humans (fast spindle number, density on Cz > Fz). For fast spindles, density was higher in females, and increased with age. These effects were more pronounced among intact animals and on Fz. Slow spindle density declined and fast spindle frequency increased with age on Cz, while on Fz age-related amplitude decline was observed. The frequency of fast spindles on Fz and slow spindles on Cz was linked to both sex and neutering, suggesting modulation by sexual hormones. Intact females displayed higher frequencies than males and neutered females. Our findings support the argument that sigma bursts in the canine non-REM sleep are analogous to human sleep spindles, and suggest that slow and fast spindles display different trajectories related to age, of which an increase in frontal fast spindles is unique to dogs. |
| first_indexed | 2024-12-20T21:50:36Z |
| format | Article |
| id | doaj.art-03f05717368149a9b5e19ae3bea5769c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:50:36Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-03f05717368149a9b5e19ae3bea5769c2022-12-21T19:25:33ZengNature PortfolioScientific Reports2045-23222019-07-019111110.1038/s41598-019-46434-yAge-related differences and sexual dimorphism in canine sleep spindlesIvaylo Borislavov Iotchev0Anna Kis1Borbála Turcsán2Daniel Rodrigo Tejeda Fernández de Lara3Vivien Reicher4Enikő Kubinyi5Department of Ethology, Eötvös Loránd UniversityInstitute of Cognitive Neuroscience and Psychology, Hungarian Academy of SciencesDepartment of Ethology, Eötvös Loránd UniversityFaculty of Veterinary Medicine and Animal Husbandry, National Autonomous University of MexicoDepartment of Ethology, Eötvös Loránd UniversityDepartment of Ethology, Eötvös Loránd UniversityAbstract Non-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investigated a large sample (N = 155) of intact and neutered pet dogs of both sexes, varying in breed and age, searching for spindles in segments of non-REM sleep. We recorded EEG from both a frontal midline electrode (Fz) and a central midline electrode (Cz) in 55.5% of the dogs, in the remaining animals only the Fz electrode was active (bipolar derivation). A similar topography was observed for fast (≥13 Hz) spindle occurrence as in humans (fast spindle number, density on Cz > Fz). For fast spindles, density was higher in females, and increased with age. These effects were more pronounced among intact animals and on Fz. Slow spindle density declined and fast spindle frequency increased with age on Cz, while on Fz age-related amplitude decline was observed. The frequency of fast spindles on Fz and slow spindles on Cz was linked to both sex and neutering, suggesting modulation by sexual hormones. Intact females displayed higher frequencies than males and neutered females. Our findings support the argument that sigma bursts in the canine non-REM sleep are analogous to human sleep spindles, and suggest that slow and fast spindles display different trajectories related to age, of which an increase in frontal fast spindles is unique to dogs.https://doi.org/10.1038/s41598-019-46434-y |
| spellingShingle | Ivaylo Borislavov Iotchev Anna Kis Borbála Turcsán Daniel Rodrigo Tejeda Fernández de Lara Vivien Reicher Enikő Kubinyi Age-related differences and sexual dimorphism in canine sleep spindles Scientific Reports |
| title | Age-related differences and sexual dimorphism in canine sleep spindles |
| title_full | Age-related differences and sexual dimorphism in canine sleep spindles |
| title_fullStr | Age-related differences and sexual dimorphism in canine sleep spindles |
| title_full_unstemmed | Age-related differences and sexual dimorphism in canine sleep spindles |
| title_short | Age-related differences and sexual dimorphism in canine sleep spindles |
| title_sort | age related differences and sexual dimorphism in canine sleep spindles |
| url | https://doi.org/10.1038/s41598-019-46434-y |
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