Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients
Objectives: The effects of anesthesia techniques and anesthetics on different systems and organs of the body, especially the immune system, in older patients undergoing surgery, have always been of interest to researchers. This study aims to compare the effects of general anesthesia with isoflurane...
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| Format: | Article |
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University of Social Welfare & Rehabilitation Sciences
2021-02-01
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| Series: | Sālmand |
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| Online Access: | http://salmandj.uswr.ac.ir/article-1-2053-en.html |
| _version_ | 1797727395803824128 |
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| author | Raheleh Alimoradzadeh Mohammad Amin Abbasi Forough Zabihi Hossein Mirmiranpour |
| author_facet | Raheleh Alimoradzadeh Mohammad Amin Abbasi Forough Zabihi Hossein Mirmiranpour |
| author_sort | Raheleh Alimoradzadeh |
| collection | DOAJ |
| description | Objectives: The effects of anesthesia techniques and anesthetics on different systems and organs of the body, especially the immune system, in older patients undergoing surgery, have always been of interest to researchers. This study aims to compare the effects of general anesthesia with isoflurane and spinal anesthesia with lidocaine on oxidative and antioxidant parameters in older patients with inguinal hernia surgery.
Methods & Materials: This is a double-blinded randomized clinical trial with parallel design conducted on 70 older patients referred to the surgery department of hospitals in Tehran, Iran during 2018-2019. They were randomly divided into two groups of 35; the first group received general anesthesia with isoflurane and the second group received spinal anesthesia with lidocaine. Blood sampling was performed in two stages; one day before and one day after surgery. Advanced Glycation End Products (AGEs), Advanced Oxidation Protein Products (AOPP), Malondialdehyde (MDA), oxidized Low-Density Lipoprotein (LDL), Ferric-Reducing Ability of Plasma (FRAP), glutathione peroxidase, superoxide dismutase and catalase levels were measured before and after anesthesia using standard methods. Collected data were analyzed in SPSS v.22 software.
Results: The Mean±SD age of patients in the lidocaine group was 69.94±8.31 years and in the isoflurane as 70.23±4.98 (P>0.81). In the isoflurane group, there was a significant difference between pre- and postoperative levels of AOPP, MDA, oxidized LDL, FRAP, catalase, glutathione peroxidase and superoxide dismutase. In the lidocaine group, this difference was significant in MDA, oxidized LDL, catalase and superoxide dismutase.
Conclusion: Given the positive effects of isoflurane on oxidative and antioxidant parameters in older patients with inguinal hernia surgery, it is recommended that this anesthetic be considered in the selection of anesthesia methods and drugs for this group of older patients. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1735-806X 1735-806X |
| language | fas |
| last_indexed | 2024-03-12T10:59:09Z |
| publishDate | 2021-02-01 |
| publisher | University of Social Welfare & Rehabilitation Sciences |
| record_format | Article |
| series | Sālmand |
| spelling | doaj.art-03f06be3637e4034baf95cbf8360583c2023-09-02T05:52:30ZfasUniversity of Social Welfare & Rehabilitation SciencesSālmand1735-806X1735-806X2021-02-01154524533Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older PatientsRaheleh Alimoradzadeh0Mohammad Amin Abbasi1Forough Zabihi2Hossein Mirmiranpour3 Clinical Research Development Unit, Firoozabadi Hospital, Iran University of Medical Sciences, Tehran, Iran. Clinical Research Development Unit, Firoozabadi Hospital, Iran University of Medical Sciences, Tehran, Iran. Clinical Research Development Unit, Firoozabadi Hospital, Iran University of Medical Sciences, Tehran, Iran. Endocrinology and Metabolism Research Center, Vali-Asr Hospital, Tehran University of Medical of Sciences, Tehran, Iran. Objectives: The effects of anesthesia techniques and anesthetics on different systems and organs of the body, especially the immune system, in older patients undergoing surgery, have always been of interest to researchers. This study aims to compare the effects of general anesthesia with isoflurane and spinal anesthesia with lidocaine on oxidative and antioxidant parameters in older patients with inguinal hernia surgery. Methods & Materials: This is a double-blinded randomized clinical trial with parallel design conducted on 70 older patients referred to the surgery department of hospitals in Tehran, Iran during 2018-2019. They were randomly divided into two groups of 35; the first group received general anesthesia with isoflurane and the second group received spinal anesthesia with lidocaine. Blood sampling was performed in two stages; one day before and one day after surgery. Advanced Glycation End Products (AGEs), Advanced Oxidation Protein Products (AOPP), Malondialdehyde (MDA), oxidized Low-Density Lipoprotein (LDL), Ferric-Reducing Ability of Plasma (FRAP), glutathione peroxidase, superoxide dismutase and catalase levels were measured before and after anesthesia using standard methods. Collected data were analyzed in SPSS v.22 software. Results: The Mean±SD age of patients in the lidocaine group was 69.94±8.31 years and in the isoflurane as 70.23±4.98 (P>0.81). In the isoflurane group, there was a significant difference between pre- and postoperative levels of AOPP, MDA, oxidized LDL, FRAP, catalase, glutathione peroxidase and superoxide dismutase. In the lidocaine group, this difference was significant in MDA, oxidized LDL, catalase and superoxide dismutase. Conclusion: Given the positive effects of isoflurane on oxidative and antioxidant parameters in older patients with inguinal hernia surgery, it is recommended that this anesthetic be considered in the selection of anesthesia methods and drugs for this group of older patients.http://salmandj.uswr.ac.ir/article-1-2053-en.htmlanesthesiainguinal herniaisofluranelidocaineoxidantantioxidant |
| spellingShingle | Raheleh Alimoradzadeh Mohammad Amin Abbasi Forough Zabihi Hossein Mirmiranpour Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients Sālmand anesthesia inguinal hernia isoflurane lidocaine oxidant antioxidant |
| title | Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients |
| title_full | Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients |
| title_fullStr | Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients |
| title_full_unstemmed | Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients |
| title_short | Effect of Anesthetics on Oxidant and Antioxidant Parameters After Inguinal Hernia Surgery in Older Patients |
| title_sort | effect of anesthetics on oxidant and antioxidant parameters after inguinal hernia surgery in older patients |
| topic | anesthesia inguinal hernia isoflurane lidocaine oxidant antioxidant |
| url | http://salmandj.uswr.ac.ir/article-1-2053-en.html |
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