Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age

Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age

In 2010, the WHO recommended an increase in the daily doses of first-line anti-tuberculosis medicines in children. We aim to characterize the pharmacokinetics of the once-daily isoniazid (INH) dose at 10 mg/kg of body weight in infants <6 months of age. We performed a multicenter pharmacokinetic...

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Bibliographic Details
Main Authors: Maria Goretti López-Ramos, Joan Vinent, Rob Aarnoutse, Angela Colbers, Eneritz Velasco-Arnaiz, Loreto Martorell, Lola Falcón-Neyra, Olaf Neth, Luis Prieto, Sara Guillén, Fernando Baquero-Artigao, Ana Méndez-Echevarría, David Gómez-Pastrana, Ana Belén Jiménez, Rebeca Lahoz, José Tomás Ramos-Amador, Antoni Soriano-Arandes, Begoña Santiago, Rosa Farré, Clàudia Fortuny, Dolors Soy, Antoni Noguera-Julian
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antibiotics
Subjects:
acetylation
infant
isoniazid
pharmacokinetics
transaminases
tuberculosis
Online Access:https://www.mdpi.com/2079-6382/12/2/272

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