Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19?
India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. ‘Original antigenic sin,’ in which a prior exposur...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-10-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2021.1945904 |
| _version_ | 1797673283935535104 |
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| author | Vipin M. Vashishtha |
| author_facet | Vipin M. Vashishtha |
| author_sort | Vipin M. Vashishtha |
| collection | DOAJ |
| description | India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. ‘Original antigenic sin,’ in which a prior exposure to an antigen leads to an ineffective response to a related antigen, may offer one immunological explanation for this unusual association. There is an urgent need of undertaking a detailed study to prove/disprove this association. |
| first_indexed | 2024-03-11T21:42:17Z |
| format | Article |
| id | doaj.art-03f498a2850245f881a2ff191a24364d |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:42:17Z |
| publishDate | 2021-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-03f498a2850245f881a2ff191a24364d2023-09-26T12:47:03ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-10-0117103314331510.1080/21645515.2021.19459041945904Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19?Vipin M. Vashishtha0Mangla Hospital & Research CenterIndia is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. ‘Original antigenic sin,’ in which a prior exposure to an antigen leads to an ineffective response to a related antigen, may offer one immunological explanation for this unusual association. There is an urgent need of undertaking a detailed study to prove/disprove this association.http://dx.doi.org/10.1080/21645515.2021.1945904covid-19original antigenic sinvaccines |
| spellingShingle | Vipin M. Vashishtha Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? Human Vaccines & Immunotherapeutics covid-19 original antigenic sin vaccines |
| title | Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? |
| title_full | Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? |
| title_fullStr | Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? |
| title_full_unstemmed | Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? |
| title_short | Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? |
| title_sort | is original antigenic sin complicating indian vaccination drive against covid 19 |
| topic | covid-19 original antigenic sin vaccines |
| url | http://dx.doi.org/10.1080/21645515.2021.1945904 |
| work_keys_str_mv | AT vipinmvashishtha isoriginalantigenicsincomplicatingindianvaccinationdriveagainstcovid19 |