Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration
In the search of a new biomaterial for the treatment of bone defects resulting from traumatic events, an osteoporosis scenario with bone fractures, tumor removal, congenital pathologies or implant revisions for infection, we developed 3D scaffolds based on mesoporous bioactive glasses (MBGs) (85 − x...
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MDPI AG
2020-12-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/23/5526 |
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| author | Javier Jiménez-Holguín Alvaro López-Hidalgo Sandra Sánchez-Salcedo Juan Peña María Vallet-Regí Antonio J. Salinas |
| author_facet | Javier Jiménez-Holguín Alvaro López-Hidalgo Sandra Sánchez-Salcedo Juan Peña María Vallet-Regí Antonio J. Salinas |
| author_sort | Javier Jiménez-Holguín |
| collection | DOAJ |
| description | In the search of a new biomaterial for the treatment of bone defects resulting from traumatic events, an osteoporosis scenario with bone fractures, tumor removal, congenital pathologies or implant revisions for infection, we developed 3D scaffolds based on mesoporous bioactive glasses (MBGs) (85 − x)SiO<sub>2</sub>–5P<sub>2</sub>O<sub>5</sub>–10CaO–xSrO (x = 0, 2.5 and 5 mol.%). The scaffolds with meso-macroporosity were fabricated by pouring a suspension of MBG powders in polyvinyl alcohol (PVA) into a negative template of polylactic acid (PLA), followed by removal of the template by extraction at low temperature. SrO-containing MBGs exhibited excellent properties for bone substitution including ordered mesoporous structure, high textural properties, quick in vitro bioactive response in simulated body fluid (SBF) and the ability of releasing concentrations of strontium ions able to stimulate expression of early markers of osteoblastic differentiation. Moreover, the direct contact of MC3T3-E1 pre-osteoblastic cells with the scaffolds confirmed the cytocompatibility of the three compositions investigated. Nevertheless, the scaffold containing 2.5% of SrO induced the best cellular proliferation showing the potential of this scaffold as a candidate to be further investigated in vitro and in vivo, aiming to be clinically used for bone regeneration applications in non-load bearing sites. |
| first_indexed | 2024-03-10T14:20:02Z |
| format | Article |
| id | doaj.art-03f55fb30a5a43dd904264f8f73e6748 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T14:20:02Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-03f55fb30a5a43dd904264f8f73e67482023-11-20T23:24:28ZengMDPI AGMaterials1996-19442020-12-011323552610.3390/ma13235526Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone RegenerationJavier Jiménez-Holguín0Alvaro López-Hidalgo1Sandra Sánchez-Salcedo2Juan Peña3María Vallet-Regí4Antonio J. Salinas5Department of Química en Ciencias Farmacéuticas, Faculty of Farmacia, Instituto de Investigación Hospital 12 de Octubre, imas12, Universidad Complutense, UCM, 28040 Madrid, SpainDepartment of Química en Ciencias Farmacéuticas, Faculty of Farmacia, Instituto de Investigación Hospital 12 de Octubre, imas12, Universidad Complutense, UCM, 28040 Madrid, SpainDepartment of Química en Ciencias Farmacéuticas, Faculty of Farmacia, Instituto de Investigación Hospital 12 de Octubre, imas12, Universidad Complutense, UCM, 28040 Madrid, SpainDepartment of Química en Ciencias Farmacéuticas, Faculty of Farmacia, Instituto de Investigación Hospital 12 de Octubre, imas12, Universidad Complutense, UCM, 28040 Madrid, SpainDepartment of Química en Ciencias Farmacéuticas, Faculty of Farmacia, Instituto de Investigación Hospital 12 de Octubre, imas12, Universidad Complutense, UCM, 28040 Madrid, SpainDepartment of Química en Ciencias Farmacéuticas, Faculty of Farmacia, Instituto de Investigación Hospital 12 de Octubre, imas12, Universidad Complutense, UCM, 28040 Madrid, SpainIn the search of a new biomaterial for the treatment of bone defects resulting from traumatic events, an osteoporosis scenario with bone fractures, tumor removal, congenital pathologies or implant revisions for infection, we developed 3D scaffolds based on mesoporous bioactive glasses (MBGs) (85 − x)SiO<sub>2</sub>–5P<sub>2</sub>O<sub>5</sub>–10CaO–xSrO (x = 0, 2.5 and 5 mol.%). The scaffolds with meso-macroporosity were fabricated by pouring a suspension of MBG powders in polyvinyl alcohol (PVA) into a negative template of polylactic acid (PLA), followed by removal of the template by extraction at low temperature. SrO-containing MBGs exhibited excellent properties for bone substitution including ordered mesoporous structure, high textural properties, quick in vitro bioactive response in simulated body fluid (SBF) and the ability of releasing concentrations of strontium ions able to stimulate expression of early markers of osteoblastic differentiation. Moreover, the direct contact of MC3T3-E1 pre-osteoblastic cells with the scaffolds confirmed the cytocompatibility of the three compositions investigated. Nevertheless, the scaffold containing 2.5% of SrO induced the best cellular proliferation showing the potential of this scaffold as a candidate to be further investigated in vitro and in vivo, aiming to be clinically used for bone regeneration applications in non-load bearing sites.https://www.mdpi.com/1996-1944/13/23/5526mesoporous glass scaffoldsSrOcytocompatibilitypre-osteoblastic cells |
| spellingShingle | Javier Jiménez-Holguín Alvaro López-Hidalgo Sandra Sánchez-Salcedo Juan Peña María Vallet-Regí Antonio J. Salinas Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration Materials mesoporous glass scaffolds SrO cytocompatibility pre-osteoblastic cells |
| title | Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration |
| title_full | Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration |
| title_fullStr | Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration |
| title_full_unstemmed | Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration |
| title_short | Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration |
| title_sort | strontium modified scaffolds based on mesoporous bioactive glasses polyvinyl alcohol composites for bone regeneration |
| topic | mesoporous glass scaffolds SrO cytocompatibility pre-osteoblastic cells |
| url | https://www.mdpi.com/1996-1944/13/23/5526 |
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