Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations
Abstract The Ugi reaction, a multicomponent reaction, allows diversity‐oriented synthesis Its importance is recognized by an exponential increase in the publications utilizing the post‐Ugi transformations as a strategy to build complex molecules via simple and sustainable processes in the recent lit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-04-01
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| Series: | ChemistryOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/open.202200223 |
| _version_ | 1797839580202795008 |
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| author | Rinkal B. Bhoraniya Dr. Sachin G. Modha |
| author_facet | Rinkal B. Bhoraniya Dr. Sachin G. Modha |
| author_sort | Rinkal B. Bhoraniya |
| collection | DOAJ |
| description | Abstract The Ugi reaction, a multicomponent reaction, allows diversity‐oriented synthesis Its importance is recognized by an exponential increase in the publications utilizing the post‐Ugi transformations as a strategy to build complex molecules via simple and sustainable processes in the recent literature. A second concept, alkyne activation through metal‐, acid‐, iodine‐catalysis and base‐mediated transformations, also leads to wonderful molecules in short and efficient synthetic routes. Combination of these two approaches via application of an alkyne‐containing component in the Ugi reaction brings the benefits of both protocols into one synthetic sequence. The propargyl amines come as an obvious choice in this context as they work wonderfully as an amine component in the Ugi reaction, while post‐Ugi alkyne activation has the potential to generate biologically interesting carbo‐ and hetero‐cyclic systems. Thus, one can compare the Ugi adduct with a pupa which has inherent property of metamorphosis into biologically interesting molecules. In this review, application of propargyl amines in the Ugi reaction is discussed with a focus on post‐Ugi transformations. |
| first_indexed | 2024-04-09T16:00:13Z |
| format | Article |
| id | doaj.art-03f740765efb4da0a69457bcc3bead1a |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-04-09T16:00:13Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-03f740765efb4da0a69457bcc3bead1a2023-04-25T12:04:55ZengWiley-VCHChemistryOpen2191-13632023-04-01124n/an/a10.1002/open.202200223Propargyl Amines: Versatile Building Blocks in Post‐Ugi TransformationsRinkal B. Bhoraniya0Dr. Sachin G. Modha1Laboratory of Organic Chemistry Tarsadia Institute of Chemical Science Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar Bardoli-Mahuva Road Tarsadi 394350 Surat, Gujarat IndiaLaboratory of Organic Chemistry Tarsadia Institute of Chemical Science Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar Bardoli-Mahuva Road Tarsadi 394350 Surat, Gujarat IndiaAbstract The Ugi reaction, a multicomponent reaction, allows diversity‐oriented synthesis Its importance is recognized by an exponential increase in the publications utilizing the post‐Ugi transformations as a strategy to build complex molecules via simple and sustainable processes in the recent literature. A second concept, alkyne activation through metal‐, acid‐, iodine‐catalysis and base‐mediated transformations, also leads to wonderful molecules in short and efficient synthetic routes. Combination of these two approaches via application of an alkyne‐containing component in the Ugi reaction brings the benefits of both protocols into one synthetic sequence. The propargyl amines come as an obvious choice in this context as they work wonderfully as an amine component in the Ugi reaction, while post‐Ugi alkyne activation has the potential to generate biologically interesting carbo‐ and hetero‐cyclic systems. Thus, one can compare the Ugi adduct with a pupa which has inherent property of metamorphosis into biologically interesting molecules. In this review, application of propargyl amines in the Ugi reaction is discussed with a focus on post‐Ugi transformations.https://doi.org/10.1002/open.202200223alkyne activationmulticomponent reactionspropargyl aminestransition metal catalysisUgi reaction |
| spellingShingle | Rinkal B. Bhoraniya Dr. Sachin G. Modha Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations ChemistryOpen alkyne activation multicomponent reactions propargyl amines transition metal catalysis Ugi reaction |
| title | Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations |
| title_full | Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations |
| title_fullStr | Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations |
| title_full_unstemmed | Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations |
| title_short | Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations |
| title_sort | propargyl amines versatile building blocks in post ugi transformations |
| topic | alkyne activation multicomponent reactions propargyl amines transition metal catalysis Ugi reaction |
| url | https://doi.org/10.1002/open.202200223 |
| work_keys_str_mv | AT rinkalbbhoraniya propargylaminesversatilebuildingblocksinpostugitransformations AT drsachingmodha propargylaminesversatilebuildingblocksinpostugitransformations |