Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine
A series of small molecules containing polar aromatic substituents and alkynes have been synthesized. One–pot preparations of polar aromatic molecules containing an alkynyl imine and alkynyl amide are reported. A one-pot preparation of a catechol containing an alkynyl amine was also attempted but in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2021/2/M1206 |
| _version_ | 1797536286949507072 |
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| author | Surya R. Banks Kyung Min Yoo Mark E. Welker |
| author_facet | Surya R. Banks Kyung Min Yoo Mark E. Welker |
| author_sort | Surya R. Banks |
| collection | DOAJ |
| description | A series of small molecules containing polar aromatic substituents and alkynes have been synthesized. One–pot preparations of polar aromatic molecules containing an alkynyl imine and alkynyl amide are reported. A one-pot preparation of a catechol containing an alkynyl amine was also attempted but in our hands it proved much better to synthesize this target molecule via a three step synthesis which we also report here. |
| first_indexed | 2024-03-10T11:57:33Z |
| format | Article |
| id | doaj.art-03f7fbce7891491a84f154a105f3304a |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T11:57:33Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-03f7fbce7891491a84f154a105f3304a2023-11-21T17:08:21ZengMDPI AGMolbank1422-85992021-04-0120212M120610.3390/M1206Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl AmineSurya R. Banks0Kyung Min Yoo1Mark E. Welker2Department of Chemistry, Wake Forest University, Winston-Salem, NC 27101, USADepartment of Chemistry, Wake Forest University, Winston-Salem, NC 27101, USACenter for Functional Materials, Department of Chemistry, Wake Forest University, Winston-Salem, NC 27101, USAA series of small molecules containing polar aromatic substituents and alkynes have been synthesized. One–pot preparations of polar aromatic molecules containing an alkynyl imine and alkynyl amide are reported. A one-pot preparation of a catechol containing an alkynyl amine was also attempted but in our hands it proved much better to synthesize this target molecule via a three step synthesis which we also report here.https://www.mdpi.com/1422-8599/2021/2/M1206catecholalkynethiol-alkyne click reaction |
| spellingShingle | Surya R. Banks Kyung Min Yoo Mark E. Welker Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine Molbank catechol alkyne thiol-alkyne click reaction |
| title | Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine |
| title_full | Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine |
| title_fullStr | Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine |
| title_full_unstemmed | Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine |
| title_short | Synthesis of Polar Aromatic Substituted Terminal Alkynes from Propargyl Amine |
| title_sort | synthesis of polar aromatic substituted terminal alkynes from propargyl amine |
| topic | catechol alkyne thiol-alkyne click reaction |
| url | https://www.mdpi.com/1422-8599/2021/2/M1206 |
| work_keys_str_mv | AT suryarbanks synthesisofpolararomaticsubstitutedterminalalkynesfrompropargylamine AT kyungminyoo synthesisofpolararomaticsubstitutedterminalalkynesfrompropargylamine AT markewelker synthesisofpolararomaticsubstitutedterminalalkynesfrompropargylamine |