Immunotherapies catering to the unmet medical need of cold colorectal cancer
As a common malignant tumor of gastrointestinal tract, the incidence of colorectal cancer (CRC) has gradually increased in recent years. In western developed countries, it has even become the second largest malignant tumor next to lung cancer. Immunotherapy is a hot topic in the field of cancer ther...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-10-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022190/full |
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author | Jun Yuan Jiarui Li Ce Gao Chun Jiang Ze Xiang Jian Wu |
author_facet | Jun Yuan Jiarui Li Ce Gao Chun Jiang Ze Xiang Jian Wu |
author_sort | Jun Yuan |
collection | DOAJ |
description | As a common malignant tumor of gastrointestinal tract, the incidence of colorectal cancer (CRC) has gradually increased in recent years. In western developed countries, it has even become the second largest malignant tumor next to lung cancer. Immunotherapy is a hot topic in the field of cancer therapy, including immune checkpoint blockade (ICB), adoptive cell therapy (ACT), cancer vaccines and cytokines, aiming to improve the ability of the immune system to recognize, target and eliminate cancer cells. However, cold CRC, which accounts for a high proportion of CRC, is not so reactive to it. The development of immunotherapy to prevent cancer cells from forming “immune escape” pathways to the immune system in cold CRC, has been under increasing study attention. There is proof that an organic combination of radiotherapy, chemotherapy, and several immunotherapies can considerably boost the immune system’s capacity to eradicate tumor cells. In this review, we summarized the role of immunotherapy in colorectal cancer. In addition, we propose a breakthrough and strategy to improve the role of immunotherapy in cold CRC based on its characteristics. |
first_indexed | 2024-04-11T10:33:08Z |
format | Article |
id | doaj.art-03f9e6867b1e454399c938f94881bdac |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-11T10:33:08Z |
publishDate | 2022-10-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-03f9e6867b1e454399c938f94881bdac2022-12-22T04:29:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10221901022190Immunotherapies catering to the unmet medical need of cold colorectal cancerJun Yuan0Jiarui Li1Ce Gao2Chun Jiang3Ze Xiang4Jian Wu5Department of Clinical Laboratory, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, Yancheng, ChinaZhejiang University School of Medicine, Hangzhou, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaZhejiang University School of Medicine, Hangzhou, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaAs a common malignant tumor of gastrointestinal tract, the incidence of colorectal cancer (CRC) has gradually increased in recent years. In western developed countries, it has even become the second largest malignant tumor next to lung cancer. Immunotherapy is a hot topic in the field of cancer therapy, including immune checkpoint blockade (ICB), adoptive cell therapy (ACT), cancer vaccines and cytokines, aiming to improve the ability of the immune system to recognize, target and eliminate cancer cells. However, cold CRC, which accounts for a high proportion of CRC, is not so reactive to it. The development of immunotherapy to prevent cancer cells from forming “immune escape” pathways to the immune system in cold CRC, has been under increasing study attention. There is proof that an organic combination of radiotherapy, chemotherapy, and several immunotherapies can considerably boost the immune system’s capacity to eradicate tumor cells. In this review, we summarized the role of immunotherapy in colorectal cancer. In addition, we propose a breakthrough and strategy to improve the role of immunotherapy in cold CRC based on its characteristics.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022190/fullcold colorectal cancerimmune checkpoint inhibitors (ICIs)adoptive cell therapy (ACT)cancer vaccinescytokines |
spellingShingle | Jun Yuan Jiarui Li Ce Gao Chun Jiang Ze Xiang Jian Wu Immunotherapies catering to the unmet medical need of cold colorectal cancer Frontiers in Immunology cold colorectal cancer immune checkpoint inhibitors (ICIs) adoptive cell therapy (ACT) cancer vaccines cytokines |
title | Immunotherapies catering to the unmet medical need of cold colorectal cancer |
title_full | Immunotherapies catering to the unmet medical need of cold colorectal cancer |
title_fullStr | Immunotherapies catering to the unmet medical need of cold colorectal cancer |
title_full_unstemmed | Immunotherapies catering to the unmet medical need of cold colorectal cancer |
title_short | Immunotherapies catering to the unmet medical need of cold colorectal cancer |
title_sort | immunotherapies catering to the unmet medical need of cold colorectal cancer |
topic | cold colorectal cancer immune checkpoint inhibitors (ICIs) adoptive cell therapy (ACT) cancer vaccines cytokines |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022190/full |
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