An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions
Metabolic rewiring requires the mobilization of fatty acids (FA) from lipid droplets (LDs) at membrane contact sites (MCSs), although the details of FA transfer remain unclear. Here, the authors show that VPS13D and the ESCRT complex remodel LD membranes to promote FA trafficking to mitochondria.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21525-5 |
| _version_ | 1818999442846515200 |
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| author | Jingru Wang Na Fang Juan Xiong Yuanjiao Du Yue Cao Wei-Ke Ji |
| author_facet | Jingru Wang Na Fang Juan Xiong Yuanjiao Du Yue Cao Wei-Ke Ji |
| author_sort | Jingru Wang |
| collection | DOAJ |
| description | Metabolic rewiring requires the mobilization of fatty acids (FA) from lipid droplets (LDs) at membrane contact sites (MCSs), although the details of FA transfer remain unclear. Here, the authors show that VPS13D and the ESCRT complex remodel LD membranes to promote FA trafficking to mitochondria. |
| first_indexed | 2024-12-20T22:17:30Z |
| format | Article |
| id | doaj.art-03fa235d34f14508a5ddd8c3dd10f798 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T22:17:30Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-03fa235d34f14508a5ddd8c3dd10f7982022-12-21T19:25:01ZengNature PortfolioNature Communications2041-17232021-02-0112111610.1038/s41467-021-21525-5An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactionsJingru Wang0Na Fang1Juan Xiong2Yuanjiao Du3Yue Cao4Wei-Ke Ji5Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyMetabolic rewiring requires the mobilization of fatty acids (FA) from lipid droplets (LDs) at membrane contact sites (MCSs), although the details of FA transfer remain unclear. Here, the authors show that VPS13D and the ESCRT complex remodel LD membranes to promote FA trafficking to mitochondria.https://doi.org/10.1038/s41467-021-21525-5 |
| spellingShingle | Jingru Wang Na Fang Juan Xiong Yuanjiao Du Yue Cao Wei-Ke Ji An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions Nature Communications |
| title | An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions |
| title_full | An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions |
| title_fullStr | An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions |
| title_full_unstemmed | An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions |
| title_short | An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions |
| title_sort | escrt dependent step in fatty acid transfer from lipid droplets to mitochondria through vps13d tsg101 interactions |
| url | https://doi.org/10.1038/s41467-021-21525-5 |
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