Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast cancer. However, survival gains have not been uniform across patients, even within a given molecular subtype. Large collections of publicly available drug screening data mat...

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Bibliographic Details
Main Authors: Jean Berthelet, Momeneh Foroutan, Dharmesh D. Bhuva, Holly J. Whitfield, Farrah El-Saafin, Joseph Cursons, Antonin Serrano, Michal Merdas, Elgene Lim, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Matthias Ernst, Frédéric Hollande, Robin L. Anderson, Bhupinder Pal, Belinda Yeo, Melissa J. Davis, Delphine Merino
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
breast cancer
pharmacogenomics
predictive modeling
drug sensitivity
precision medicine
cisplatin
Online Access:https://www.mdpi.com/2072-6694/14/10/2404

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