Influence of Vein Injury in Different Methods of Chemotherapy in Mice
OBJECTIVE To explore the effects of cisplatin chemotherapy via the vein and the abdominal cavity on the functions of endothelial cells of mice with non-small cell lung cancer.METHODS 75 mice were divided equally into a untreated group, a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2011-06-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/51 |
| _version_ | 1818190446382284800 |
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| author | Yong Li Zhi Guo Xiu-ying Guo Zhe Wang Wen-ge Xing |
| author_facet | Yong Li Zhi Guo Xiu-ying Guo Zhe Wang Wen-ge Xing |
| author_sort | Yong Li |
| collection | DOAJ |
| description | OBJECTIVE To explore the effects of cisplatin chemotherapy via the vein and the abdominal cavity on the functions of endothelial cells of mice with non-small cell lung cancer.METHODS 75 mice were divided equally into a untreated group, a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL) via an intravenousmethod and a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL) via an intraperitoneal method; changes in the morphology and ultrastructure of vein endothelial cells were observed.RESULTS The injury of the intima of the intravenous chemotherapy groupwas similar to that of the intraperitoneal chemotherapy group.CONCLUSION The injury of vein endothelial cells is not significantly related to the choice of intravenous injection or intraperitoneal injection. |
| first_indexed | 2024-12-11T23:58:51Z |
| format | Article |
| id | doaj.art-03fd5fff00aa49a0a9c92de63f50f23f |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-12-11T23:58:51Z |
| publishDate | 2011-06-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-03fd5fff00aa49a0a9c92de63f50f23f2022-12-22T00:45:16ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412011-06-018210010510.1007/s11805-011-0566-8Influence of Vein Injury in Different Methods of Chemotherapy in MiceYong LiZhi GuoXiu-ying GuoZhe WangWen-ge XingOBJECTIVE To explore the effects of cisplatin chemotherapy via the vein and the abdominal cavity on the functions of endothelial cells of mice with non-small cell lung cancer.METHODS 75 mice were divided equally into a untreated group, a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL) via an intravenousmethod and a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL) via an intraperitoneal method; changes in the morphology and ultrastructure of vein endothelial cells were observed.RESULTS The injury of the intima of the intravenous chemotherapy groupwas similar to that of the intraperitoneal chemotherapy group.CONCLUSION The injury of vein endothelial cells is not significantly related to the choice of intravenous injection or intraperitoneal injection.http://www.cancerbiomed.org/index.php/cocr/article/view/51micenon-small cell lung cancerchemotherapyvascular endothelial cellinjury |
| spellingShingle | Yong Li Zhi Guo Xiu-ying Guo Zhe Wang Wen-ge Xing Influence of Vein Injury in Different Methods of Chemotherapy in Mice Cancer Biology & Medicine mice non-small cell lung cancer chemotherapy vascular endothelial cell injury |
| title | Influence of Vein Injury in Different Methods of Chemotherapy in Mice |
| title_full | Influence of Vein Injury in Different Methods of Chemotherapy in Mice |
| title_fullStr | Influence of Vein Injury in Different Methods of Chemotherapy in Mice |
| title_full_unstemmed | Influence of Vein Injury in Different Methods of Chemotherapy in Mice |
| title_short | Influence of Vein Injury in Different Methods of Chemotherapy in Mice |
| title_sort | influence of vein injury in different methods of chemotherapy in mice |
| topic | mice non-small cell lung cancer chemotherapy vascular endothelial cell injury |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/51 |
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