Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy?
Genetic testing for breast and ovarian cancer can help target prevention programs, and possibly reduce morbidity and mortality. A positive result of BRCA1/2 is a substantial risk factor for breast and ovarian cancer, and its detection often leads to risk reduction interventions such as increased scr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2015-07-01
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| Series: | Judgment and Decision Making |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1930297500005180/type/journal_article |
| _version_ | 1797697937567907840 |
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| author | Talya Miron-Shatz Yaniv Hanoch Benjamin A. Katz Glen M. Doniger Elissa M. Ozanne |
| author_facet | Talya Miron-Shatz Yaniv Hanoch Benjamin A. Katz Glen M. Doniger Elissa M. Ozanne |
| author_sort | Talya Miron-Shatz |
| collection | DOAJ |
| description | Genetic testing for breast and ovarian cancer can help target prevention programs, and possibly reduce morbidity and mortality. A positive result of BRCA1/2 is a substantial risk factor for breast and ovarian cancer, and its detection often leads to risk reduction interventions such as increased screening, prophylactic mastectomy and oophorectomy. We examined predictors of the decision to undergo cancer related genetic testing: perceived risk, family risk of breast or ovarian cancer, and numeracy as predictors of the decision to test among women at high risk of breast cancer. Stepwise regression analysis of survey responses from 459 women registered in the Cancer Genetics Network revealed greater likelihood to test for women with more family history, higher perceived risk of mutation, or Ashkenazi descent. Neither subjective nor objective numeracy was associated with the decision to test, although we replicated an earlier finding that subjective numeracy predicted willingness to pay for testing. Findings underscore the need for genetic counselling that disentangles risk perception from objective information to promote better decision-making in the context of genetic testing. Highlighting these factors is crucial for public health campaigns, as well as to clinic-based testing and direct-to-consumer testing. |
| first_indexed | 2024-03-12T03:47:07Z |
| format | Article |
| id | doaj.art-03fe6c6fa645412fa108b49e4e538933 |
| institution | Directory Open Access Journal |
| issn | 1930-2975 |
| language | English |
| last_indexed | 2024-03-12T03:47:07Z |
| publishDate | 2015-07-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Judgment and Decision Making |
| spelling | doaj.art-03fe6c6fa645412fa108b49e4e5389332023-09-03T12:43:18ZengCambridge University PressJudgment and Decision Making1930-29752015-07-011038639910.1017/S1930297500005180Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy?Talya Miron-Shatz0Yaniv Hanoch1Benjamin A. Katz2Glen M. Doniger3Elissa M. Ozanne4Center forMedical DecisionMaking, Ono Academic College, 104 Zahal St., Kiryat Ono 55000, IsraelSchool of Psychology, Plymouth University, UKDepartment of Psychology, Hebrew University of Jerusalem,IsraelCenter for Medical Decision Making, Ono Academic College, IsraelDartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, USAGenetic testing for breast and ovarian cancer can help target prevention programs, and possibly reduce morbidity and mortality. A positive result of BRCA1/2 is a substantial risk factor for breast and ovarian cancer, and its detection often leads to risk reduction interventions such as increased screening, prophylactic mastectomy and oophorectomy. We examined predictors of the decision to undergo cancer related genetic testing: perceived risk, family risk of breast or ovarian cancer, and numeracy as predictors of the decision to test among women at high risk of breast cancer. Stepwise regression analysis of survey responses from 459 women registered in the Cancer Genetics Network revealed greater likelihood to test for women with more family history, higher perceived risk of mutation, or Ashkenazi descent. Neither subjective nor objective numeracy was associated with the decision to test, although we replicated an earlier finding that subjective numeracy predicted willingness to pay for testing. Findings underscore the need for genetic counselling that disentangles risk perception from objective information to promote better decision-making in the context of genetic testing. Highlighting these factors is crucial for public health campaigns, as well as to clinic-based testing and direct-to-consumer testing.https://www.cambridge.org/core/product/identifier/S1930297500005180/type/journal_articlewillingness to testgenetic testingbreast cancerBRCA1 and 2subjective numeracyfamily history. early detection |
| spellingShingle | Talya Miron-Shatz Yaniv Hanoch Benjamin A. Katz Glen M. Doniger Elissa M. Ozanne Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy? Judgment and Decision Making willingness to test genetic testing breast cancer BRCA1 and 2 subjective numeracy family history. early detection |
| title | Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy? |
| title_full | Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy? |
| title_fullStr | Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy? |
| title_full_unstemmed | Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy? |
| title_short | Willingness to test for BRCA1/2 in high risk women: Influenced by risk perception and family experience, rather than by objective or subjective numeracy? |
| title_sort | willingness to test for brca1 2 in high risk women influenced by risk perception and family experience rather than by objective or subjective numeracy |
| topic | willingness to test genetic testing breast cancer BRCA1 and 2 subjective numeracy family history. early detection |
| url | https://www.cambridge.org/core/product/identifier/S1930297500005180/type/journal_article |
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