Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population
Yao Liu,1– 3 Jinqing Liu,1– 3 Lei Fu,1– 3 Chuan Jiang,1– 3 Shifang Peng1– 3 1Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Key Laboratory of Viral Hepatitis of Hunan Province, Xiangya Hospital, Central South University, Changsha...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-02-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/demographics-and-clinical-outcomes-of-culture-positive-versus-culture--peer-reviewed-fulltext-article-IDR |
| _version_ | 1828013867644485632 |
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| author | Liu Y Liu J Fu L Jiang C Peng S |
| author_facet | Liu Y Liu J Fu L Jiang C Peng S |
| author_sort | Liu Y |
| collection | DOAJ |
| description | Yao Liu,1– 3 Jinqing Liu,1– 3 Lei Fu,1– 3 Chuan Jiang,1– 3 Shifang Peng1– 3 1Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Key Laboratory of Viral Hepatitis of Hunan Province, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaCorrespondence: Shifang Peng, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, People’s Republic of China, Email sfp1988@csu.edu.cnObjective: Despite its high case-fatality risk, pyogenic liver abscess (PLA) lacks clear management guidelines in patients with negative microbial cultures. Our aim was to evaluate differences in clinical characteristics between patients with culture-negative liver abscess (CNLA) and those with culture-positive liver abscess (CPLA), and identify differences in the main causative pathogen.Methods: In this study, we retrospectively collected medical records of PLA patients admitted to a teaching hospital from January 2010 to December 2019.Results: In total, 324 PLA patients were enrolled in this study. Of these, 202 (62.3%) cases were confirmed cultural positive, including 109 patients (54%) and 20 (9.9%) patients infected with Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E.coli), respectively. Patients in the CPLA group were older (p=0.029) and had higher prevalence of abscesses larger than 5 cm in diameter (p = 0.003), gas-forming rate (p = 0.016), and percutaneous drainage (p < 0.001) compared with CNLA group. Patients with CPLA had significantly longer hospitalizations than those with CNLA (p = 0.010). Nevertheless, there was no significant difference in in-hospital mortality between the two groups (p = 0.415). Compared with patients with E. coli, those with K. pneumoniae had higher incidence of diabetes mellitus (p = 0.041), solitary abscess (p < 0.001), localization in the right hepatic lobe (p = 0.033), abscess size larger than 5 cm (p < 0.001) and percutaneous drainage (p = 0.002), but mortality was not significantly different (p = 1.000).Conclusion: No significant difference in in-hospital mortality was found between patients with CNLA and those with CPLA group. However, clinical characteristics and management were different between the main causative pathogens, including K. pneumoniae and E. coli.Keywords: PLA, culture negative, culture positive, Klebsiella pneumoniae, Escherichia coli |
| first_indexed | 2024-04-10T09:51:38Z |
| format | Article |
| id | doaj.art-03fe771bb8944936ad6aba4029e86932 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-10T09:51:38Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-03fe771bb8944936ad6aba4029e869322023-02-16T18:07:27ZengDove Medical PressInfection and Drug Resistance1178-69732023-02-01Volume 1690391181681Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian PopulationLiu YLiu JFu LJiang CPeng SYao Liu,1– 3 Jinqing Liu,1– 3 Lei Fu,1– 3 Chuan Jiang,1– 3 Shifang Peng1– 3 1Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Key Laboratory of Viral Hepatitis of Hunan Province, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaCorrespondence: Shifang Peng, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, People’s Republic of China, Email sfp1988@csu.edu.cnObjective: Despite its high case-fatality risk, pyogenic liver abscess (PLA) lacks clear management guidelines in patients with negative microbial cultures. Our aim was to evaluate differences in clinical characteristics between patients with culture-negative liver abscess (CNLA) and those with culture-positive liver abscess (CPLA), and identify differences in the main causative pathogen.Methods: In this study, we retrospectively collected medical records of PLA patients admitted to a teaching hospital from January 2010 to December 2019.Results: In total, 324 PLA patients were enrolled in this study. Of these, 202 (62.3%) cases were confirmed cultural positive, including 109 patients (54%) and 20 (9.9%) patients infected with Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E.coli), respectively. Patients in the CPLA group were older (p=0.029) and had higher prevalence of abscesses larger than 5 cm in diameter (p = 0.003), gas-forming rate (p = 0.016), and percutaneous drainage (p < 0.001) compared with CNLA group. Patients with CPLA had significantly longer hospitalizations than those with CNLA (p = 0.010). Nevertheless, there was no significant difference in in-hospital mortality between the two groups (p = 0.415). Compared with patients with E. coli, those with K. pneumoniae had higher incidence of diabetes mellitus (p = 0.041), solitary abscess (p < 0.001), localization in the right hepatic lobe (p = 0.033), abscess size larger than 5 cm (p < 0.001) and percutaneous drainage (p = 0.002), but mortality was not significantly different (p = 1.000).Conclusion: No significant difference in in-hospital mortality was found between patients with CNLA and those with CPLA group. However, clinical characteristics and management were different between the main causative pathogens, including K. pneumoniae and E. coli.Keywords: PLA, culture negative, culture positive, Klebsiella pneumoniae, Escherichia colihttps://www.dovepress.com/demographics-and-clinical-outcomes-of-culture-positive-versus-culture--peer-reviewed-fulltext-article-IDRpyogenic liver abscessculture negativeculture positiveklebsiella pneumoniaeescherichia coli |
| spellingShingle | Liu Y Liu J Fu L Jiang C Peng S Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population Infection and Drug Resistance pyogenic liver abscess culture negative culture positive klebsiella pneumoniae escherichia coli |
| title | Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population |
| title_full | Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population |
| title_fullStr | Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population |
| title_full_unstemmed | Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population |
| title_short | Demographics and Clinical Outcomes of Culture-Positive versus Culture-Negative Pyogenic Liver Abscess in an Asian Population |
| title_sort | demographics and clinical outcomes of culture positive versus culture negative pyogenic liver abscess in an asian population |
| topic | pyogenic liver abscess culture negative culture positive klebsiella pneumoniae escherichia coli |
| url | https://www.dovepress.com/demographics-and-clinical-outcomes-of-culture-positive-versus-culture--peer-reviewed-fulltext-article-IDR |
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