Discordant immunohistochemistry in an unusual MLH1 gene variant in a case of Lynch syndrome

Discordant immunohistochemistry in an unusual MLH1 gene variant in a case of Lynch syndrome

Immunohistochemistry for mismatch repair proteins and microsatellite instability testing are recommended screening methods for Lynch syndrome. They have a good sensitivity and specificity, allowing for directed genetic testing and diagnosis. We report a case of Lynch syndrome with retained MMR prote...

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Bibliographic Details
Main Authors: Prerana Nagabhushana, Snigdha Kumari, Minakshi Rohilla, Radhika Srinivasan, Aashima Arora, Pulkit Rastogi
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Gynecologic Oncology Reports
Subjects:
Endometrial cancer
Lynch syndrome
Mismatch repair protein
Immunohistochemistry
MLH1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578921001582

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