Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression
Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. Between 2018 and 2021, we prospectively enrolled 280 patients who underwent renal biopsy and were divided into three groups based on...
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MDPI AG
2022-03-01
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| Cyfres: | Biomedicines |
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| Mynediad Ar-lein: | https://www.mdpi.com/2227-9059/10/3/585 |
| _version_ | 1827649854717820928 |
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| author | Shuo-Ming Ou Ming-Tsun Tsai Huan-Yuan Chen Fu-An Li Kuo-Hua Lee Wei-Cheng Tseng Fu-Pang Chang Yao-Ping Lin Ruey-Bing Yang Der-Cherng Tarng |
| author_facet | Shuo-Ming Ou Ming-Tsun Tsai Huan-Yuan Chen Fu-An Li Kuo-Hua Lee Wei-Cheng Tseng Fu-Pang Chang Yao-Ping Lin Ruey-Bing Yang Der-Cherng Tarng |
| author_sort | Shuo-Ming Ou |
| collection | DOAJ |
| description | Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. Between 2018 and 2021, we prospectively enrolled 280 patients who underwent renal biopsy and were divided into three groups based on their urinary Gal-3 levels (<354.6, 354.6–510.7, and ≥510.8 pg/mL) to assess kidney disease progression (defined as ≥40% decline in the estimated glomerular filtration rate or end-stage renal disease) and renal histology findings. Patients in the highest urinary Gal-3 tertile had the lowest eGFRs and highest proteinuria levels. In multivariate Cox regression models, patients in the highest tertile had the highest risk of kidney disease progression (adjusted hazard ratio, 4.60; 95% confidence interval, 2.85–7.71) compared to those in the lowest tertile. Higher urinary Gal-3 levels were associated with more severe renal fibrosis. Intrarenal mRNA expression of LGALS3 (Gal-3-encoded gene) was most correlated with the renal stress biomarkers (IGFBP7 and TIMB2), renal function biomarkers (PTGDS) and fibrosis-associated genes (TGFB1). The urinary Gal-3 level may be useful for the identification of patients at high risk of kidney disease progression and renal fibrosis, and for the early initiation of treatments for these patients. |
| first_indexed | 2024-03-09T20:05:25Z |
| format | Article |
| id | doaj.art-03fff19d94bb401bb7a2a363f584f7aa |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:25Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-03fff19d94bb401bb7a2a363f584f7aa2023-11-24T00:32:22ZengMDPI AGBiomedicines2227-90592022-03-0110358510.3390/biomedicines10030585Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease ProgressionShuo-Ming Ou0Ming-Tsun Tsai1Huan-Yuan Chen2Fu-An Li3Kuo-Hua Lee4Wei-Cheng Tseng5Fu-Pang Chang6Yao-Ping Lin7Ruey-Bing Yang8Der-Cherng Tarng9Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei 115201, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei 115201, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei 115201, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112201, TaiwanPlasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. Between 2018 and 2021, we prospectively enrolled 280 patients who underwent renal biopsy and were divided into three groups based on their urinary Gal-3 levels (<354.6, 354.6–510.7, and ≥510.8 pg/mL) to assess kidney disease progression (defined as ≥40% decline in the estimated glomerular filtration rate or end-stage renal disease) and renal histology findings. Patients in the highest urinary Gal-3 tertile had the lowest eGFRs and highest proteinuria levels. In multivariate Cox regression models, patients in the highest tertile had the highest risk of kidney disease progression (adjusted hazard ratio, 4.60; 95% confidence interval, 2.85–7.71) compared to those in the lowest tertile. Higher urinary Gal-3 levels were associated with more severe renal fibrosis. Intrarenal mRNA expression of LGALS3 (Gal-3-encoded gene) was most correlated with the renal stress biomarkers (IGFBP7 and TIMB2), renal function biomarkers (PTGDS) and fibrosis-associated genes (TGFB1). The urinary Gal-3 level may be useful for the identification of patients at high risk of kidney disease progression and renal fibrosis, and for the early initiation of treatments for these patients.https://www.mdpi.com/2227-9059/10/3/585galectin-3kidney disease progressionrenal biopsyrenal fibrosisurinary biomarkers |
| spellingShingle | Shuo-Ming Ou Ming-Tsun Tsai Huan-Yuan Chen Fu-An Li Kuo-Hua Lee Wei-Cheng Tseng Fu-Pang Chang Yao-Ping Lin Ruey-Bing Yang Der-Cherng Tarng Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression Biomedicines galectin-3 kidney disease progression renal biopsy renal fibrosis urinary biomarkers |
| title | Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression |
| title_full | Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression |
| title_fullStr | Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression |
| title_full_unstemmed | Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression |
| title_short | Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression |
| title_sort | urinary galectin 3 as a novel biomarker for the prediction of renal fibrosis and kidney disease progression |
| topic | galectin-3 kidney disease progression renal biopsy renal fibrosis urinary biomarkers |
| url | https://www.mdpi.com/2227-9059/10/3/585 |
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