Genomewide Transcriptional Responses of Iron-Starved <named-content content-type="genus-species">Chlamydia trachomatis</named-content> Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation

Genomewide Transcriptional Responses of Iron-Starved <named-content content-type="genus-species">Chlamydia trachomatis</named-content> Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation

ABSTRACT Iron is essential for growth and development of Chlamydia. Its long-term starvation in cultured mammalian cells leads to production of aberrant noninfectious chlamydial forms, also known as persistence. Immediate transcriptional responses to iron limitation have not been characterized, leav...

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Bibliographic Details
Main Authors: Amanda J. Brinkworth, Mark R. Wildung, Rey A. Carabeo
Format: Article
Language:English
Published: American Society for Microbiology 2018-02-01
Series:mSystems
Subjects:
Chlamydia
microbiology
global regulatory networks
intracellular bacteria
iron reduction
stress response
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00184-17

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