Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3
The authors report the Cryo-EM of hnRNPDL-2 fibrils. The structure highlights features of a functional amyloid associated with limb-girdle muscular dystrophy-3 and explains how alternative splicing controls the assembly of this ribonucleoprotein.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35854-0 |
| _version_ | 1828056757474164736 |
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| author | Javier Garcia-Pardo Andrea Bartolomé-Nafría Antonio Chaves-Sanjuan Marcos Gil-Garcia Cristina Visentin Martino Bolognesi Stefano Ricagno Salvador Ventura |
| author_facet | Javier Garcia-Pardo Andrea Bartolomé-Nafría Antonio Chaves-Sanjuan Marcos Gil-Garcia Cristina Visentin Martino Bolognesi Stefano Ricagno Salvador Ventura |
| author_sort | Javier Garcia-Pardo |
| collection | DOAJ |
| description | The authors report the Cryo-EM of hnRNPDL-2 fibrils. The structure highlights features of a functional amyloid associated with limb-girdle muscular dystrophy-3 and explains how alternative splicing controls the assembly of this ribonucleoprotein. |
| first_indexed | 2024-04-10T21:00:35Z |
| format | Article |
| id | doaj.art-0400f8a9115f463985ae38d8abefa7e7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T21:00:35Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0400f8a9115f463985ae38d8abefa7e72023-01-22T12:18:54ZengNature PortfolioNature Communications2041-17232023-01-0114111210.1038/s41467-023-35854-0Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3Javier Garcia-Pardo0Andrea Bartolomé-Nafría1Antonio Chaves-Sanjuan2Marcos Gil-Garcia3Cristina Visentin4Martino Bolognesi5Stefano Ricagno6Salvador Ventura7Institut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de BarcelonaInstitut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de BarcelonaDipartimento di Bioscienze, Università degli Studi di MilanoInstitut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de BarcelonaDipartimento di Bioscienze, Università degli Studi di MilanoDipartimento di Bioscienze, Università degli Studi di MilanoDipartimento di Bioscienze, Università degli Studi di MilanoInstitut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de BarcelonaThe authors report the Cryo-EM of hnRNPDL-2 fibrils. The structure highlights features of a functional amyloid associated with limb-girdle muscular dystrophy-3 and explains how alternative splicing controls the assembly of this ribonucleoprotein.https://doi.org/10.1038/s41467-023-35854-0 |
| spellingShingle | Javier Garcia-Pardo Andrea Bartolomé-Nafría Antonio Chaves-Sanjuan Marcos Gil-Garcia Cristina Visentin Martino Bolognesi Stefano Ricagno Salvador Ventura Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 Nature Communications |
| title | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 |
| title_full | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 |
| title_fullStr | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 |
| title_full_unstemmed | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 |
| title_short | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 |
| title_sort | cryo em structure of hnrnpdl 2 fibrils a functional amyloid associated with limb girdle muscular dystrophy d3 |
| url | https://doi.org/10.1038/s41467-023-35854-0 |
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