In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter.

In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter.

The Hedgehog (Hh) pathway is essential for embryonic development and tissue regeneration, and its dysregulation can lead to birth defects and tumorigenesis. Understanding how this signaling mechanism contributes to these processes would benefit from an ability to visualize Hedgehog pathway activity...

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Bibliographic Details
Main Authors: John K Mich, Alexander Y Payumo, Paul G Rack, James K Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4113417?pdf=render

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