Promising use of nanotechnology in Pythium insidiosum: a systematic review
ABSTRACT: The aquatic oomycete Pythium insidiosum is an emerging pathogen highly relevant in human and veterinary medicine and an etiologic agent of pythiosis, a disease of worldwide distribution mainly affecting horses, dogs, and humans, presenting cutaneous, subcutaneous, ocular, gastrointestinal,...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Santa Maria
2022-11-01
|
| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000700452&tlng=en |
| _version_ | 1811322644877803520 |
|---|---|
| author | Lara Baccarin Ianiski Aline Fontanella Maciel Caroline Quintana Braga Carla Weiblen Daniela Isabel Brayer Pereira Luís Antônio Sangioni Janio Morais Santurio Luciana Pötter Sônia de Avila Botton |
| author_facet | Lara Baccarin Ianiski Aline Fontanella Maciel Caroline Quintana Braga Carla Weiblen Daniela Isabel Brayer Pereira Luís Antônio Sangioni Janio Morais Santurio Luciana Pötter Sônia de Avila Botton |
| author_sort | Lara Baccarin Ianiski |
| collection | DOAJ |
| description | ABSTRACT: The aquatic oomycete Pythium insidiosum is an emerging pathogen highly relevant in human and veterinary medicine and an etiologic agent of pythiosis, a disease of worldwide distribution mainly affecting horses, dogs, and humans, presenting cutaneous, subcutaneous, ocular, gastrointestinal, and systemic forms. The available therapeutic methods to treat this disease and its forms are not entirely effective, thus highlighting the need to investigate the forms of treatments with better efficacy, such as compounds from different pharmacological classes, compounds of natural origin, and new technological alternatives, including nanotechnology. Therefore, this study evaluated scientific publications regarding the use of nanotechnology in P. insidiosum treatment. For this, a systematic literature review, was carried out on articles published from 2010 to 2022 on the LILACS, MEDLINE, Google Scholar, PubMed, and SciELO databases using the descriptors ‘Pythium insidiosum,’ ‘pythiosis,’ ‘nanotechnology,’ ‘nanoparticles,’ ‘nanoemulsion,’ and ‘treatment.’ We reported 162 articles for the researched theme; although, only four studies were included because they met the criteria established herein. A meta-analysis was used for the statistical analysis of the data obtained in vitro studies, and we reported the use of nanotechnology can be a promising alternative in developing antimicrobial compounds with anti-P. insidiosum activity. Nevertheless, additional research is needed to verify the potential use of this technology in clinical therapy against P. insidiosum infections. |
| first_indexed | 2024-04-13T13:38:41Z |
| format | Article |
| id | doaj.art-0401797d2300432587dc2cea46818c5a |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-04-13T13:38:41Z |
| publishDate | 2022-11-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-0401797d2300432587dc2cea46818c5a2022-12-22T02:44:41ZengUniversidade Federal de Santa MariaCiência Rural1678-45962022-11-0153710.1590/0103-8478cr20220091Promising use of nanotechnology in Pythium insidiosum: a systematic reviewLara Baccarin Ianiskihttps://orcid.org/0000-0002-4992-3610Aline Fontanella Macielhttps://orcid.org/0000-0002-9770-1932Caroline Quintana Bragahttps://orcid.org/0000-0003-1481-9829Carla Weiblenhttps://orcid.org/0000-0001-9782-9971Daniela Isabel Brayer Pereirahttps://orcid.org/0000-0003-4374-677XLuís Antônio Sangionihttps://orcid.org/0000-0002-2364-1084Janio Morais Santuriohttps://orcid.org/0000-0001-6286-9076Luciana Pötterhttps://orcid.org/0000-0002-6288-4468Sônia de Avila Bottonhttps://orcid.org/0000-0002-8855-9217ABSTRACT: The aquatic oomycete Pythium insidiosum is an emerging pathogen highly relevant in human and veterinary medicine and an etiologic agent of pythiosis, a disease of worldwide distribution mainly affecting horses, dogs, and humans, presenting cutaneous, subcutaneous, ocular, gastrointestinal, and systemic forms. The available therapeutic methods to treat this disease and its forms are not entirely effective, thus highlighting the need to investigate the forms of treatments with better efficacy, such as compounds from different pharmacological classes, compounds of natural origin, and new technological alternatives, including nanotechnology. Therefore, this study evaluated scientific publications regarding the use of nanotechnology in P. insidiosum treatment. For this, a systematic literature review, was carried out on articles published from 2010 to 2022 on the LILACS, MEDLINE, Google Scholar, PubMed, and SciELO databases using the descriptors ‘Pythium insidiosum,’ ‘pythiosis,’ ‘nanotechnology,’ ‘nanoparticles,’ ‘nanoemulsion,’ and ‘treatment.’ We reported 162 articles for the researched theme; although, only four studies were included because they met the criteria established herein. A meta-analysis was used for the statistical analysis of the data obtained in vitro studies, and we reported the use of nanotechnology can be a promising alternative in developing antimicrobial compounds with anti-P. insidiosum activity. Nevertheless, additional research is needed to verify the potential use of this technology in clinical therapy against P. insidiosum infections.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000700452&tlng=ennanotechnologyoomycetePythiosisPythium insidiosumsusceptibility. |
| spellingShingle | Lara Baccarin Ianiski Aline Fontanella Maciel Caroline Quintana Braga Carla Weiblen Daniela Isabel Brayer Pereira Luís Antônio Sangioni Janio Morais Santurio Luciana Pötter Sônia de Avila Botton Promising use of nanotechnology in Pythium insidiosum: a systematic review Ciência Rural nanotechnology oomycete Pythiosis Pythium insidiosum susceptibility. |
| title | Promising use of nanotechnology in Pythium insidiosum: a systematic review |
| title_full | Promising use of nanotechnology in Pythium insidiosum: a systematic review |
| title_fullStr | Promising use of nanotechnology in Pythium insidiosum: a systematic review |
| title_full_unstemmed | Promising use of nanotechnology in Pythium insidiosum: a systematic review |
| title_short | Promising use of nanotechnology in Pythium insidiosum: a systematic review |
| title_sort | promising use of nanotechnology in pythium insidiosum a systematic review |
| topic | nanotechnology oomycete Pythiosis Pythium insidiosum susceptibility. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000700452&tlng=en |
| work_keys_str_mv | AT larabaccarinianiski promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT alinefontanellamaciel promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT carolinequintanabraga promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT carlaweiblen promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT danielaisabelbrayerpereira promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT luisantoniosangioni promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT janiomoraissanturio promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT lucianapotter promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview AT soniadeavilabotton promisinguseofnanotechnologyinpythiuminsidiosumasystematicreview |