Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma
Renal Ewing sarcoma (ES) is a rare malignant tumor characterized by fusion of the EWSR1 gene with a member of the ETS family of oncogenes, arising at a specific chromosomal translocation. Diagnosis of ES can be problematic, especially from cytological or small bioptical specimens because the differe...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Cytology |
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| Online Access: | http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=1;spage=30;epage=32;aulast=Yamamoto |
| _version_ | 1818036185747947520 |
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| author | Yoshinari Yamamoto Kazuto Yamazaki Yasuo Ishida |
| author_facet | Yoshinari Yamamoto Kazuto Yamazaki Yasuo Ishida |
| author_sort | Yoshinari Yamamoto |
| collection | DOAJ |
| description | Renal Ewing sarcoma (ES) is a rare malignant tumor characterized by fusion of the EWSR1 gene with a member of the ETS family of oncogenes, arising at a specific chromosomal translocation. Diagnosis of ES can be problematic, especially from cytological or small bioptical specimens because the differential diagnoses comprising a diverse group of small round blue cell tumors (SRBCTs). We report a case of primary renal ES in a young male, which had a t(11;22) (q24;q12) chromosome translocation encoding a type2 EWSR1/FLI1 fusion transcript. The tumor cells showed diffuse cytoplasmic immunoreactivity for CD99 and diffuse nuclear immunoreactivity for NKX2.2, an important oncogenic transcriptional target of EWSR1/FLI1, not only in the histological, but also in the cytological specimens. From the results of this case, we speculate that NKX2.2, in combination with CD99, may be a useful immunocytochemical marker to distinguish renal ES from other SRBCTs of kidney. |
| first_indexed | 2024-12-10T07:06:56Z |
| format | Article |
| id | doaj.art-0401c1464676411991c3b96044f14f0c |
| institution | Directory Open Access Journal |
| issn | 0970-9371 |
| language | English |
| last_indexed | 2024-12-10T07:06:56Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cytology |
| spelling | doaj.art-0401c1464676411991c3b96044f14f0c2022-12-22T01:58:10ZengWolters Kluwer Medknow PublicationsJournal of Cytology0970-93712015-01-01321303210.4103/0970-9371.155229Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcomaYoshinari YamamotoKazuto YamazakiYasuo IshidaRenal Ewing sarcoma (ES) is a rare malignant tumor characterized by fusion of the EWSR1 gene with a member of the ETS family of oncogenes, arising at a specific chromosomal translocation. Diagnosis of ES can be problematic, especially from cytological or small bioptical specimens because the differential diagnoses comprising a diverse group of small round blue cell tumors (SRBCTs). We report a case of primary renal ES in a young male, which had a t(11;22) (q24;q12) chromosome translocation encoding a type2 EWSR1/FLI1 fusion transcript. The tumor cells showed diffuse cytoplasmic immunoreactivity for CD99 and diffuse nuclear immunoreactivity for NKX2.2, an important oncogenic transcriptional target of EWSR1/FLI1, not only in the histological, but also in the cytological specimens. From the results of this case, we speculate that NKX2.2, in combination with CD99, may be a useful immunocytochemical marker to distinguish renal ES from other SRBCTs of kidney.http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=1;spage=30;epage=32;aulast=YamamotoCD99; Ewing sarcoma; immunocytochemistry; kidney neoplasm; NKX2.2 |
| spellingShingle | Yoshinari Yamamoto Kazuto Yamazaki Yasuo Ishida Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma Journal of Cytology CD99; Ewing sarcoma; immunocytochemistry; kidney neoplasm; NKX2.2 |
| title | Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma |
| title_full | Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma |
| title_fullStr | Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma |
| title_full_unstemmed | Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma |
| title_short | Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma |
| title_sort | upregulation of nkx2 2 a target of ewsr1 fli1 fusion transcript in primary renal ewing sarcoma |
| topic | CD99; Ewing sarcoma; immunocytochemistry; kidney neoplasm; NKX2.2 |
| url | http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=1;spage=30;epage=32;aulast=Yamamoto |
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