Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

Polo-like kinase 1 (PLK1) is a key cell cycle regulator implicated in the development of various cancers, including prostate cancer. However, the functions of PLK1 beyond cell cycle regulation remain poorly characterized. Here, we report that PLK1 overexpression in prostate epithelial cells triggers...

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Bibliographic Details
Main Authors: Jianguo Wu, Andrei I Ivanov, Paul B Fisher, Zheng Fu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
polo-like kinase 1
epithelial-to-mesenchymal transition
cell migration
CRAF
prostate cancer
invasion
Online Access:https://elifesciences.org/articles/10734

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