Promoter Demethylation Upregulates <i>STEAP1</i> Gene Expression in Human Prostate Cancer: In Vitro and In Silico Analysis

Promoter Demethylation Upregulates <i>STEAP1</i> Gene Expression in Human Prostate Cancer: In Vitro and In Silico Analysis

The Six Transmembrane Epithelial Antigen of the Prostate (<i>STEAP1</i>) is an oncogene overexpressed in several human tumors, particularly in prostate cancer (PCa). However, the mechanisms involved in its overexpression remain unknown. It is well known that epigenetic modifications may...

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Bibliographic Details
Main Authors: Sandra M. Rocha, Inês Sousa, Inês M. Gomes, Patrícia Arinto, Pedro Costa-Pinheiro, Eduarda Coutinho, Cecília R. Santos, Carmen Jerónimo, Manuel C. Lemos, Luís A. Passarinha, Sílvia Socorro, Cláudio J. Maia
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Life
Subjects:
prostate cancer
<i>STEAP1</i>
DNA methylation
histone deacetylation
bioinformatics
Online Access:https://www.mdpi.com/2075-1729/11/11/1251

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