Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors
Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oesophagus.
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Nature Portfolio
2018-10-01
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| سلاسل: | Nature Communications |
| الوصول للمادة أونلاين: | https://doi.org/10.1038/s41467-018-06385-w |
| _version_ | 1831578619643691008 |
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| author | Luca Urbani Carlotta Camilli Demetra-Ellie Phylactopoulos Claire Crowley Dipa Natarajan Federico Scottoni Panayiotis Maghsoudlou Conor J. McCann Alessandro Filippo Pellegata Anna Urciuolo Koichi Deguchi Sahira Khalaf Salvatore Ferdinando Aruta Maria Cristina Signorelli David Kiely Edward Hannon Matteo Trevisan Rui Rachel Wong Marc Olivier Baradez Dale Moulding Alex Virasami Asllan Gjinovci Stavros Loukogeorgakis Sara Mantero Nikhil Thapar Neil Sebire Simon Eaton Mark Lowdell Giulio Cossu Paola Bonfanti Paolo De Coppi |
| author_facet | Luca Urbani Carlotta Camilli Demetra-Ellie Phylactopoulos Claire Crowley Dipa Natarajan Federico Scottoni Panayiotis Maghsoudlou Conor J. McCann Alessandro Filippo Pellegata Anna Urciuolo Koichi Deguchi Sahira Khalaf Salvatore Ferdinando Aruta Maria Cristina Signorelli David Kiely Edward Hannon Matteo Trevisan Rui Rachel Wong Marc Olivier Baradez Dale Moulding Alex Virasami Asllan Gjinovci Stavros Loukogeorgakis Sara Mantero Nikhil Thapar Neil Sebire Simon Eaton Mark Lowdell Giulio Cossu Paola Bonfanti Paolo De Coppi |
| author_sort | Luca Urbani |
| collection | DOAJ |
| description | Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oesophagus. |
| first_indexed | 2024-12-17T16:14:13Z |
| format | Article |
| id | doaj.art-04035db7e1a6472b9d4fc0a2bd25b51a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T16:14:13Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-04035db7e1a6472b9d4fc0a2bd25b51a2022-12-21T21:41:43ZengNature PortfolioNature Communications2041-17232018-10-019111610.1038/s41467-018-06385-wMulti-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitorsLuca Urbani0Carlotta Camilli1Demetra-Ellie Phylactopoulos2Claire Crowley3Dipa Natarajan4Federico Scottoni5Panayiotis Maghsoudlou6Conor J. McCann7Alessandro Filippo Pellegata8Anna Urciuolo9Koichi Deguchi10Sahira Khalaf11Salvatore Ferdinando Aruta12Maria Cristina Signorelli13David Kiely14Edward Hannon15Matteo Trevisan16Rui Rachel Wong17Marc Olivier Baradez18Dale Moulding19Alex Virasami20Asllan Gjinovci21Stavros Loukogeorgakis22Sara Mantero23Nikhil Thapar24Neil Sebire25Simon Eaton26Mark Lowdell27Giulio Cossu28Paola Bonfanti29Paolo De Coppi30Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonCell and Gene Therapy CatapultStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonDepartment of Histopathology, Great Ormond Street Hospital, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonDepartment of Chemistry, Materials and Chemical Engineering “Giulio Natta”Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonRoyal Free London NHS FT & UCLDivision of Cell Matrix and Regenerative Medicine, Manchester Academic Health Centre, University of ManchesterStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of LondonCombining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oesophagus.https://doi.org/10.1038/s41467-018-06385-w |
| spellingShingle | Luca Urbani Carlotta Camilli Demetra-Ellie Phylactopoulos Claire Crowley Dipa Natarajan Federico Scottoni Panayiotis Maghsoudlou Conor J. McCann Alessandro Filippo Pellegata Anna Urciuolo Koichi Deguchi Sahira Khalaf Salvatore Ferdinando Aruta Maria Cristina Signorelli David Kiely Edward Hannon Matteo Trevisan Rui Rachel Wong Marc Olivier Baradez Dale Moulding Alex Virasami Asllan Gjinovci Stavros Loukogeorgakis Sara Mantero Nikhil Thapar Neil Sebire Simon Eaton Mark Lowdell Giulio Cossu Paola Bonfanti Paolo De Coppi Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors Nature Communications |
| title | Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors |
| title_full | Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors |
| title_fullStr | Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors |
| title_full_unstemmed | Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors |
| title_short | Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors |
| title_sort | multi stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors |
| url | https://doi.org/10.1038/s41467-018-06385-w |
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