Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region
BACKGROUND: Vitamin D binding protein is a main vitamin D carrier in serum. It also has an impact on macrophagial function. Role of vitamin D and macrophages in the pathogenesis of atherosclerosis is scientifically proven but there is lack of data on vitamin D binding protein in this regard. AIMS: T...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2019-12-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/9758 |
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| author | Robert S. Bogachev Anastasia Y. Kozel Larisa S. Litvinova Larisa V. Mikhailova Elena S. Shytova Vitaly B. Ankudоvich Vladislav V. Mordvintsev Ulyana A. Dobrynina |
| author_facet | Robert S. Bogachev Anastasia Y. Kozel Larisa S. Litvinova Larisa V. Mikhailova Elena S. Shytova Vitaly B. Ankudоvich Vladislav V. Mordvintsev Ulyana A. Dobrynina |
| author_sort | Robert S. Bogachev |
| collection | DOAJ |
| description | BACKGROUND: Vitamin D binding protein is a main vitamin D carrier in serum. It also has an impact on macrophagial function. Role of vitamin D and macrophages in the pathogenesis of atherosclerosis is scientifically proven but there is lack of data on vitamin D binding protein in this regard. AIMS: To evaluate the vitamin D binding protein polymorphism in patients with acute coronary syndrome without diabetes mellitus, autoimmune diseases and malignant tumors. Determine correlation, if there is, between vitamin D binding protein allele and features of acute coronary syndrome among this patient group. MATERIALS AND METHODS: It is a cross-sectional observational study. Study subjects are patients with acute coronary syndrome. Exclusion criteria are the presence of diabetes mellitus, autoimmune diseases and malignant tumors. In all participants were evaluated: predisposing factors for heart diseases, CBC, biochemical blood test, troponin, coronarography, echocardiography. The study lasted for 5 months from November 2017 until March 2018. Primary end point – assessment of vitamin D binding protein polymorphysm in this group of patients with acute coronary syndrome by means of vitamin D binding protein gene sequencing. 50 patients were enrolled into this study who were urgently admitted to hospital and diagnosed with acute coronary syndrome. Among them – 36 males and 14 females. Mean age was 60 (55;66) years. All participants were sequenced for single nucleotide polymorphysm in VDBP p.T436K (rs4588) and P.432E (rs7041). RESULTS: Gene polymorphysms of interest were found in 43 patients among 50 enrolled. Haplotype Gc1s/2 (rs7041G-rs4588A) was found in 7 (14%) patients, Gc2 (rs7041T-rs4588A) — in 9 (18%) patients, Gc1s (rs7041G-rs4588C) – in 20 (40%) patients, Gc1f (rs7041T-rs4588C) in 14 (28%). Coronarography showed that coronary artery occlusions obstructing more than 50% of vessel lumen was found in 16 patients; obstruction greater than 90% was seen in 8 patients; total occlusion – in 4 patients. CONCLUSIONS: In patient group with acute coronary syndrome prevalence of vitamin D binding protein gene polymorphysm was high – in 86% of participants. The features of Gc2 haplotype were higher frequency of recurrent myocardial infarction and total coronary artery occlusion, as well as tendency to decreased serum vitamin D3 (25(OH)D) levels. |
| first_indexed | 2024-03-08T09:12:51Z |
| format | Article |
| id | doaj.art-040622a113ed40d58a3ac8a038ac1535 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:27Z |
| publishDate | 2019-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-040622a113ed40d58a3ac8a038ac15352024-04-16T16:16:12ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242019-12-01163818710.14341/omet97588704Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad regionRobert S. Bogachev0Anastasia Y. Kozel1Larisa S. Litvinova2Larisa V. Mikhailova3Elena S. Shytova4Vitaly B. Ankudоvich5Vladislav V. Mordvintsev6Ulyana A. Dobrynina7Immanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityBACKGROUND: Vitamin D binding protein is a main vitamin D carrier in serum. It also has an impact on macrophagial function. Role of vitamin D and macrophages in the pathogenesis of atherosclerosis is scientifically proven but there is lack of data on vitamin D binding protein in this regard. AIMS: To evaluate the vitamin D binding protein polymorphism in patients with acute coronary syndrome without diabetes mellitus, autoimmune diseases and malignant tumors. Determine correlation, if there is, between vitamin D binding protein allele and features of acute coronary syndrome among this patient group. MATERIALS AND METHODS: It is a cross-sectional observational study. Study subjects are patients with acute coronary syndrome. Exclusion criteria are the presence of diabetes mellitus, autoimmune diseases and malignant tumors. In all participants were evaluated: predisposing factors for heart diseases, CBC, biochemical blood test, troponin, coronarography, echocardiography. The study lasted for 5 months from November 2017 until March 2018. Primary end point – assessment of vitamin D binding protein polymorphysm in this group of patients with acute coronary syndrome by means of vitamin D binding protein gene sequencing. 50 patients were enrolled into this study who were urgently admitted to hospital and diagnosed with acute coronary syndrome. Among them – 36 males and 14 females. Mean age was 60 (55;66) years. All participants were sequenced for single nucleotide polymorphysm in VDBP p.T436K (rs4588) and P.432E (rs7041). RESULTS: Gene polymorphysms of interest were found in 43 patients among 50 enrolled. Haplotype Gc1s/2 (rs7041G-rs4588A) was found in 7 (14%) patients, Gc2 (rs7041T-rs4588A) — in 9 (18%) patients, Gc1s (rs7041G-rs4588C) – in 20 (40%) patients, Gc1f (rs7041T-rs4588C) in 14 (28%). Coronarography showed that coronary artery occlusions obstructing more than 50% of vessel lumen was found in 16 patients; obstruction greater than 90% was seen in 8 patients; total occlusion – in 4 patients. CONCLUSIONS: In patient group with acute coronary syndrome prevalence of vitamin D binding protein gene polymorphysm was high – in 86% of participants. The features of Gc2 haplotype were higher frequency of recurrent myocardial infarction and total coronary artery occlusion, as well as tendency to decreased serum vitamin D3 (25(OH)D) levels.https://www.omet-endojournals.ru/jour/article/view/9758vitamin d binding proteinacute coronary syndromevitamin d binding protein polymorphysmvitamin datherosclerosis |
| spellingShingle | Robert S. Bogachev Anastasia Y. Kozel Larisa S. Litvinova Larisa V. Mikhailova Elena S. Shytova Vitaly B. Ankudоvich Vladislav V. Mordvintsev Ulyana A. Dobrynina Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region Ожирение и метаболизм vitamin d binding protein acute coronary syndrome vitamin d binding protein polymorphysm vitamin d atherosclerosis |
| title | Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region |
| title_full | Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region |
| title_fullStr | Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region |
| title_full_unstemmed | Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region |
| title_short | Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region |
| title_sort | vitamin d binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region |
| topic | vitamin d binding protein acute coronary syndrome vitamin d binding protein polymorphysm vitamin d atherosclerosis |
| url | https://www.omet-endojournals.ru/jour/article/view/9758 |
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