Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
Abstract Objective To determine the adult reference intervals for the Siemens IgG subclass reagents. Methods 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits. Results IgGSc ref...
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| Format: | Article |
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BMC
2017-10-01
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| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13223-017-0216-7 |
| _version_ | 1818191421641850880 |
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| author | Ping Li Zhongjuan Liu Ziyan Wu Xiaoting Wen Liubing Li Shulan Zhang Yingchun Xu Yongzhe Li |
| author_facet | Ping Li Zhongjuan Liu Ziyan Wu Xiaoting Wen Liubing Li Shulan Zhang Yingchun Xu Yongzhe Li |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Abstract Objective To determine the adult reference intervals for the Siemens IgG subclass reagents. Methods 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits. Results IgGSc reference intervals were as follows: IgG1 4.45–9.76 g/L, IgG2 2.07–8.57 g/L, IgG3 0.08–0.80 g/L and IgG4 0.05–1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed. Conclusions Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose. |
| first_indexed | 2024-12-12T00:14:21Z |
| format | Article |
| id | doaj.art-0406ef64ccd64c79affad833d4104388 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-12T00:14:21Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-0406ef64ccd64c79affad833d41043882022-12-22T00:44:53ZengBMCAllergy, Asthma & Clinical Immunology1710-14922017-10-011311410.1186/s13223-017-0216-7Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese populationPing Li0Zhongjuan Liu1Ziyan Wu2Xiaoting Wen3Liubing Li4Shulan Zhang5Yingchun Xu6Yongzhe Li7Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationAbstract Objective To determine the adult reference intervals for the Siemens IgG subclass reagents. Methods 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits. Results IgGSc reference intervals were as follows: IgG1 4.45–9.76 g/L, IgG2 2.07–8.57 g/L, IgG3 0.08–0.80 g/L and IgG4 0.05–1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed. Conclusions Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.http://link.springer.com/article/10.1186/s13223-017-0216-7Immunoglobulin subclassesImmunonephelometric assaysChinese population |
| spellingShingle | Ping Li Zhongjuan Liu Ziyan Wu Xiaoting Wen Liubing Li Shulan Zhang Yingchun Xu Yongzhe Li Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population Allergy, Asthma & Clinical Immunology Immunoglobulin subclasses Immunonephelometric assays Chinese population |
| title | Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population |
| title_full | Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population |
| title_fullStr | Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population |
| title_full_unstemmed | Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population |
| title_short | Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population |
| title_sort | adult reference intervals for igg subclasses with siemens immunonephelometric assays in chinese population |
| topic | Immunoglobulin subclasses Immunonephelometric assays Chinese population |
| url | http://link.springer.com/article/10.1186/s13223-017-0216-7 |
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