Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids
Background/Aims: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated. Methods: Sixty patients with type 2 DN were randomly div...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-06-01
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| Series: | Kidney & Blood Pressure Research |
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| Online Access: | https://www.karger.com/Article/FullText/490472 |
| _version_ | 1831676931784835072 |
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| author | Wei Wang |
| author_facet | Wei Wang |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Background/Aims: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated. Methods: Sixty patients with type 2 DN were randomly divided into three groups (n=20 per group): low-dose (30 mg/day TG), double-dose (60 mg/day TG) and control (placebo) groups, all three times daily for 6 months. The levels of triglycerides, total cholesterol, urinary protein, plasma albumin and serum tumour necrosis factor (TNF)-α were compared between the three groups. Results: After treatment, urinary protein and TNF-α level significantly decreased in patients in the treatment groups, compared with the control group. This decrease was significantly larger in the double-dose group than in the low-dose group. However, there was no significant decrease in triglycerides and total cholesterol in the two treatment groups. Furthermore, plasma albumin was lower in the treatment groups than in the control group. Conclusion: The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile. |
| first_indexed | 2024-12-20T04:31:52Z |
| format | Article |
| id | doaj.art-040a8ef989f343d6b2885173553f2353 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-20T04:31:52Z |
| publishDate | 2018-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-040a8ef989f343d6b2885173553f23532022-12-21T19:53:21ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432018-06-0143393193710.1159/000490472490472Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood LipidsWei WangBackground/Aims: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated. Methods: Sixty patients with type 2 DN were randomly divided into three groups (n=20 per group): low-dose (30 mg/day TG), double-dose (60 mg/day TG) and control (placebo) groups, all three times daily for 6 months. The levels of triglycerides, total cholesterol, urinary protein, plasma albumin and serum tumour necrosis factor (TNF)-α were compared between the three groups. Results: After treatment, urinary protein and TNF-α level significantly decreased in patients in the treatment groups, compared with the control group. This decrease was significantly larger in the double-dose group than in the low-dose group. However, there was no significant decrease in triglycerides and total cholesterol in the two treatment groups. Furthermore, plasma albumin was lower in the treatment groups than in the control group. Conclusion: The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile.https://www.karger.com/Article/FullText/490472Diabetic nephropathyTripterygium glycosides (TG)ProteinuriaBlood lipid |
| spellingShingle | Wei Wang Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids Kidney & Blood Pressure Research Diabetic nephropathy Tripterygium glycosides (TG) Proteinuria Blood lipid |
| title | Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids |
| title_full | Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids |
| title_fullStr | Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids |
| title_full_unstemmed | Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids |
| title_short | Different Doses of Tripterygium Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids |
| title_sort | different doses of tripterygium glycosides in the treatment of diabetic nephropathy effects on blood lipids |
| topic | Diabetic nephropathy Tripterygium glycosides (TG) Proteinuria Blood lipid |
| url | https://www.karger.com/Article/FullText/490472 |
| work_keys_str_mv | AT weiwang differentdosesoftripterygiumglycosidesinthetreatmentofdiabeticnephropathyeffectsonbloodlipids |