Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience
The tall-cell variant of papillary thyroid carcinoma (TCPTC) is the most common aggressive variant of papillary thyroid carcinoma (PTC) and typically occurs in older patients. In this study, we analyzed retrospectively the largest mono-institutional series of PTCs with tall-cell features (989 patien...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/7/2152 |
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| author | Agnese Proietti Francesca Signorini Riccardo Giannini Anello Marcello Poma Elisabetta Macerola Liborio Torregrossa Gabriele Materazzi Alessio Basolo Ferruccio Santini Rossella Elisei David Viola Fulvio Basolo Clara Ugolini |
| author_facet | Agnese Proietti Francesca Signorini Riccardo Giannini Anello Marcello Poma Elisabetta Macerola Liborio Torregrossa Gabriele Materazzi Alessio Basolo Ferruccio Santini Rossella Elisei David Viola Fulvio Basolo Clara Ugolini |
| author_sort | Agnese Proietti |
| collection | DOAJ |
| description | The tall-cell variant of papillary thyroid carcinoma (TCPTC) is the most common aggressive variant of papillary thyroid carcinoma (PTC) and typically occurs in older patients. In this study, we analyzed retrospectively the largest mono-institutional series of PTCs with tall-cell features (989 patients) over a 17-year period, re-evaluating tumors based on age at presentation and outcomes in different age groups. We divided patients into three age groups following different criteria (the criterion from the American Joint Committee on Cancer Tumor Node Metastasis (AJCC TNM) guidelines, criterion for the statistical division into tertiles and adolescent/post-adolescent criterion) to analyze the clinicopathological characteristics in different age groups, especially in terms of recurrence-free survival (RFS) and distant recurrence-free survival (DRFS). We obtained three main results: 1. the population is distributed among the different age groups, and therefore, this type of cancer is not exclusively found among those of an older age; 2. in the RFS analysis, we can see a higher probability of local recurrence in the younger and older groups and, unexpectedly, a lower probability of local recurrence in the “median age” group; and 3. in the DRFS analysis, we can observe a higher probability of distant recurrence in older patients. From a molecular perspective, no significant differences in the mutational status of <i>BRAF</i> were detected according to different age groups, while mutations in the <i>TERT</i> promoter were exclusively present in older patients of all age groups, highlighting the potential prognostic implications of <i>TERT</i> promoter mutations in PTCs. In conclusion, the results of this series confirm that TC morphology alone in PTCs does not have the same negative prognostic significance in the younger population as in the older population. The reason for these different outcomes remains unclear and needs further studies. |
| first_indexed | 2024-03-11T05:40:25Z |
| format | Article |
| id | doaj.art-040b0f13d3ca4d5a980aee8072c5090b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:40:25Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-040b0f13d3ca4d5a980aee8072c5090b2023-11-17T16:26:54ZengMDPI AGCancers2072-66942023-04-01157215210.3390/cancers15072152Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional ExperienceAgnese Proietti0Francesca Signorini1Riccardo Giannini2Anello Marcello Poma3Elisabetta Macerola4Liborio Torregrossa5Gabriele Materazzi6Alessio Basolo7Ferruccio Santini8Rossella Elisei9David Viola10Fulvio Basolo11Clara Ugolini12Section of Pathology, University Hospital of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalySection of Pathology, University Hospital of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalyUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalySection of Endocrinology, Versilia Hospital, 55041 Camaiore, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, ItalyThe tall-cell variant of papillary thyroid carcinoma (TCPTC) is the most common aggressive variant of papillary thyroid carcinoma (PTC) and typically occurs in older patients. In this study, we analyzed retrospectively the largest mono-institutional series of PTCs with tall-cell features (989 patients) over a 17-year period, re-evaluating tumors based on age at presentation and outcomes in different age groups. We divided patients into three age groups following different criteria (the criterion from the American Joint Committee on Cancer Tumor Node Metastasis (AJCC TNM) guidelines, criterion for the statistical division into tertiles and adolescent/post-adolescent criterion) to analyze the clinicopathological characteristics in different age groups, especially in terms of recurrence-free survival (RFS) and distant recurrence-free survival (DRFS). We obtained three main results: 1. the population is distributed among the different age groups, and therefore, this type of cancer is not exclusively found among those of an older age; 2. in the RFS analysis, we can see a higher probability of local recurrence in the younger and older groups and, unexpectedly, a lower probability of local recurrence in the “median age” group; and 3. in the DRFS analysis, we can observe a higher probability of distant recurrence in older patients. From a molecular perspective, no significant differences in the mutational status of <i>BRAF</i> were detected according to different age groups, while mutations in the <i>TERT</i> promoter were exclusively present in older patients of all age groups, highlighting the potential prognostic implications of <i>TERT</i> promoter mutations in PTCs. In conclusion, the results of this series confirm that TC morphology alone in PTCs does not have the same negative prognostic significance in the younger population as in the older population. The reason for these different outcomes remains unclear and needs further studies.https://www.mdpi.com/2072-6694/15/7/2152thyroid carcinomapapillary carcinomatall cellageclinical outcome |
| spellingShingle | Agnese Proietti Francesca Signorini Riccardo Giannini Anello Marcello Poma Elisabetta Macerola Liborio Torregrossa Gabriele Materazzi Alessio Basolo Ferruccio Santini Rossella Elisei David Viola Fulvio Basolo Clara Ugolini Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience Cancers thyroid carcinoma papillary carcinoma tall cell age clinical outcome |
| title | Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience |
| title_full | Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience |
| title_fullStr | Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience |
| title_full_unstemmed | Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience |
| title_short | Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience |
| title_sort | outcomes of the tall cell variant of papillary thyroid carcinoma in patients with different ages a 17 year mono institutional experience |
| topic | thyroid carcinoma papillary carcinoma tall cell age clinical outcome |
| url | https://www.mdpi.com/2072-6694/15/7/2152 |
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