Altered functional connectivity during speech perception in congenital amusia
Individuals with congenital amusia have a lifelong history of unreliable pitch processing. Accordingly, they downweight pitch cues during speech perception and instead rely on other dimensions such as duration. We investigated the neural basis for this strategy. During fMRI, individuals with amusia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/53539 |
| _version_ | 1811228027822014464 |
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| author | Kyle Jasmin Frederic Dick Lauren Stewart Adam Taylor Tierney |
| author_facet | Kyle Jasmin Frederic Dick Lauren Stewart Adam Taylor Tierney |
| author_sort | Kyle Jasmin |
| collection | DOAJ |
| description | Individuals with congenital amusia have a lifelong history of unreliable pitch processing. Accordingly, they downweight pitch cues during speech perception and instead rely on other dimensions such as duration. We investigated the neural basis for this strategy. During fMRI, individuals with amusia (N = 15) and controls (N = 15) read sentences where a comma indicated a grammatical phrase boundary. They then heard two sentences spoken that differed only in pitch and/or duration cues and selected the best match for the written sentence. Prominent reductions in functional connectivity were detected in the amusia group between left prefrontal language-related regions and right hemisphere pitch-related regions, which reflected the between-group differences in cue weights in the same groups of listeners. Connectivity differences between these regions were not present during a control task. Our results indicate that the reliability of perceptual dimensions is linked with functional connectivity between frontal and perceptual regions and suggest a compensatory mechanism. |
| first_indexed | 2024-04-12T09:51:36Z |
| format | Article |
| id | doaj.art-040b3ee56eeb48bdb05fd97c9e645c2e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:51:36Z |
| publishDate | 2020-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-040b3ee56eeb48bdb05fd97c9e645c2e2022-12-22T03:37:48ZengeLife Sciences Publications LtdeLife2050-084X2020-08-01910.7554/eLife.53539Altered functional connectivity during speech perception in congenital amusiaKyle Jasmin0https://orcid.org/0000-0001-9723-8207Frederic Dick1https://orcid.org/0000-0002-2933-3912Lauren Stewart2Adam Taylor Tierney3https://orcid.org/0000-0002-7624-6918Department of Psychological Sciences, Birkbeck University of London, London, United Kingdom; UCL Institute of Cognitive Neuroscience, University College London, London, United KingdomDepartment of Psychological Sciences, Birkbeck University of London, London, United Kingdom; Department of Experimental Psychology, University College London, London, United KingdomDepartment of Psychology, Goldsmiths University of London, London, United KingdomDepartment of Psychological Sciences, Birkbeck University of London, London, United KingdomIndividuals with congenital amusia have a lifelong history of unreliable pitch processing. Accordingly, they downweight pitch cues during speech perception and instead rely on other dimensions such as duration. We investigated the neural basis for this strategy. During fMRI, individuals with amusia (N = 15) and controls (N = 15) read sentences where a comma indicated a grammatical phrase boundary. They then heard two sentences spoken that differed only in pitch and/or duration cues and selected the best match for the written sentence. Prominent reductions in functional connectivity were detected in the amusia group between left prefrontal language-related regions and right hemisphere pitch-related regions, which reflected the between-group differences in cue weights in the same groups of listeners. Connectivity differences between these regions were not present during a control task. Our results indicate that the reliability of perceptual dimensions is linked with functional connectivity between frontal and perceptual regions and suggest a compensatory mechanism.https://elifesciences.org/articles/53539perceptionamusiaspeechfunctional connectivityfMRIauditory |
| spellingShingle | Kyle Jasmin Frederic Dick Lauren Stewart Adam Taylor Tierney Altered functional connectivity during speech perception in congenital amusia eLife perception amusia speech functional connectivity fMRI auditory |
| title | Altered functional connectivity during speech perception in congenital amusia |
| title_full | Altered functional connectivity during speech perception in congenital amusia |
| title_fullStr | Altered functional connectivity during speech perception in congenital amusia |
| title_full_unstemmed | Altered functional connectivity during speech perception in congenital amusia |
| title_short | Altered functional connectivity during speech perception in congenital amusia |
| title_sort | altered functional connectivity during speech perception in congenital amusia |
| topic | perception amusia speech functional connectivity fMRI auditory |
| url | https://elifesciences.org/articles/53539 |
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