Membrane estrogen signaling in female reproduction and motivation
Estrogen receptors were initially identified in the uterus, and later throughout the brain and body as intracellular, ligand-regulated transcription factors that affect genomic change upon ligand binding. However, rapid estrogen receptor signaling initiated outside of the nucleus was also known to o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1009379/full |
| _version_ | 1818029246598086656 |
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| author | Caroline S. Johnson Paul E Micevych Paul G. Mermelstein |
| author_facet | Caroline S. Johnson Paul E Micevych Paul G. Mermelstein |
| author_sort | Caroline S. Johnson |
| collection | DOAJ |
| description | Estrogen receptors were initially identified in the uterus, and later throughout the brain and body as intracellular, ligand-regulated transcription factors that affect genomic change upon ligand binding. However, rapid estrogen receptor signaling initiated outside of the nucleus was also known to occur via mechanisms that were less clear. Recent studies indicate that these traditional receptors, estrogen receptor-α and estrogen receptor-β, can also be trafficked to act at the surface membrane. Signaling cascades from these membrane-bound estrogen receptors (mERs) not only rapidly effect cellular excitability, but can and do ultimately affect gene expression, as seen through the phosphorylation of CREB. A principal mechanism of neuronal mER action is through glutamate-independent transactivation of metabotropic glutamate receptors (mGluRs), which elicits multiple signaling outcomes. The interaction of mERs with mGluRs has been shown to be important in many diverse functions in females, including, but not limited to, reproduction and motivation. Here we review membrane-initiated estrogen receptor signaling in females, with a focus on the interactions between these mERs and mGluRs. |
| first_indexed | 2024-12-10T05:16:38Z |
| format | Article |
| id | doaj.art-040bbe3b698c444db99e7bcb0ff5aebb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T05:16:38Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-040bbe3b698c444db99e7bcb0ff5aebb2022-12-22T02:00:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.10093791009379Membrane estrogen signaling in female reproduction and motivationCaroline S. Johnson0Paul E Micevych1Paul G. Mermelstein2Department of Neuroscience, University of Minnesota, Minneapolis, MN, United StatesLaboratory of Neuroendocrinology, Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, United StatesEstrogen receptors were initially identified in the uterus, and later throughout the brain and body as intracellular, ligand-regulated transcription factors that affect genomic change upon ligand binding. However, rapid estrogen receptor signaling initiated outside of the nucleus was also known to occur via mechanisms that were less clear. Recent studies indicate that these traditional receptors, estrogen receptor-α and estrogen receptor-β, can also be trafficked to act at the surface membrane. Signaling cascades from these membrane-bound estrogen receptors (mERs) not only rapidly effect cellular excitability, but can and do ultimately affect gene expression, as seen through the phosphorylation of CREB. A principal mechanism of neuronal mER action is through glutamate-independent transactivation of metabotropic glutamate receptors (mGluRs), which elicits multiple signaling outcomes. The interaction of mERs with mGluRs has been shown to be important in many diverse functions in females, including, but not limited to, reproduction and motivation. Here we review membrane-initiated estrogen receptor signaling in females, with a focus on the interactions between these mERs and mGluRs.https://www.frontiersin.org/articles/10.3389/fendo.2022.1009379/fullestrogenestrogen receptorsmembrane estrogen receptorsmetabotropic glutamate (mGlu) receptorsestrogen receptor signaling |
| spellingShingle | Caroline S. Johnson Paul E Micevych Paul G. Mermelstein Membrane estrogen signaling in female reproduction and motivation Frontiers in Endocrinology estrogen estrogen receptors membrane estrogen receptors metabotropic glutamate (mGlu) receptors estrogen receptor signaling |
| title | Membrane estrogen signaling in female reproduction and motivation |
| title_full | Membrane estrogen signaling in female reproduction and motivation |
| title_fullStr | Membrane estrogen signaling in female reproduction and motivation |
| title_full_unstemmed | Membrane estrogen signaling in female reproduction and motivation |
| title_short | Membrane estrogen signaling in female reproduction and motivation |
| title_sort | membrane estrogen signaling in female reproduction and motivation |
| topic | estrogen estrogen receptors membrane estrogen receptors metabotropic glutamate (mGlu) receptors estrogen receptor signaling |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1009379/full |
| work_keys_str_mv | AT carolinesjohnson membraneestrogensignalinginfemalereproductionandmotivation AT paulemicevych membraneestrogensignalinginfemalereproductionandmotivation AT paulgmermelstein membraneestrogensignalinginfemalereproductionandmotivation |