The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence
Platelet-rich fibrin (PRF) is a second-generation blood concentrate that serves as an autologous approach for both soft and hard tissue regeneration. It provides a scaffold for cell interaction and promotes the local release of growth factors. PRF has been investigated as an alternative to bone tiss...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/10/503 |
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| author | Renata de Lima Barbosa Emanuelle Stellet Lourenço Julya Vittoria de Azevedo dos Santos Neilane Rodrigues Santiago Rocha Carlos Fernando Mourão Gutemberg Gomes Alves |
| author_facet | Renata de Lima Barbosa Emanuelle Stellet Lourenço Julya Vittoria de Azevedo dos Santos Neilane Rodrigues Santiago Rocha Carlos Fernando Mourão Gutemberg Gomes Alves |
| author_sort | Renata de Lima Barbosa |
| collection | DOAJ |
| description | Platelet-rich fibrin (PRF) is a second-generation blood concentrate that serves as an autologous approach for both soft and hard tissue regeneration. It provides a scaffold for cell interaction and promotes the local release of growth factors. PRF has been investigated as an alternative to bone tissue therapy, with the potential to expedite wound healing and bone regeneration, though the mechanisms involved are not yet fully understood. This review aims to explore the in vitro evidence of PRF’s effects on the behavior of mineralizing cells related to bone tissue regeneration. A systematic electronic search was conducted up to August 2023, utilizing three databases: PubMed, Web of Science, and Scopus. A total of 76 studies were selected, which presented in vitro evidence of PRF’s usefulness, either alone or in conjunction with other biomaterials, for bone tissue treatment. PRF membranes’ influence on the proliferation, differentiation, and mineralization of bone cells is linked to the constant release of growth factors, resulting in changes in crucial markers of bone cell metabolism and behavior. This further reinforces their therapeutic potential in wound healing and bone regeneration. While there are some notable differences among the studies, the overall results suggest a positive effect of PRF on cell proliferation, differentiation, mineralization, and a reduction in inflammation. This points to its therapeutic potential in the field of regenerative medicine. Collectively, these findings may help enhance our understanding of how PRF impacts basic physiological processes in bone and mineralized tissue. |
| first_indexed | 2024-03-10T21:09:29Z |
| format | Article |
| id | doaj.art-040d677ad09549adbe390b29798cfafe |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-10T21:09:29Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-040d677ad09549adbe390b29798cfafe2023-11-19T16:55:39ZengMDPI AGJournal of Functional Biomaterials2079-49832023-10-01141050310.3390/jfb14100503The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro EvidenceRenata de Lima Barbosa0Emanuelle Stellet Lourenço1Julya Vittoria de Azevedo dos Santos2Neilane Rodrigues Santiago Rocha3Carlos Fernando Mourão4Gutemberg Gomes Alves5Clinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, BrazilClinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, BrazilClinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, BrazilClinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, BrazilDepartment of Periodontology, Tufts University School of Dental Medicine, Boston, MA 02111, USAClinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, BrazilPlatelet-rich fibrin (PRF) is a second-generation blood concentrate that serves as an autologous approach for both soft and hard tissue regeneration. It provides a scaffold for cell interaction and promotes the local release of growth factors. PRF has been investigated as an alternative to bone tissue therapy, with the potential to expedite wound healing and bone regeneration, though the mechanisms involved are not yet fully understood. This review aims to explore the in vitro evidence of PRF’s effects on the behavior of mineralizing cells related to bone tissue regeneration. A systematic electronic search was conducted up to August 2023, utilizing three databases: PubMed, Web of Science, and Scopus. A total of 76 studies were selected, which presented in vitro evidence of PRF’s usefulness, either alone or in conjunction with other biomaterials, for bone tissue treatment. PRF membranes’ influence on the proliferation, differentiation, and mineralization of bone cells is linked to the constant release of growth factors, resulting in changes in crucial markers of bone cell metabolism and behavior. This further reinforces their therapeutic potential in wound healing and bone regeneration. While there are some notable differences among the studies, the overall results suggest a positive effect of PRF on cell proliferation, differentiation, mineralization, and a reduction in inflammation. This points to its therapeutic potential in the field of regenerative medicine. Collectively, these findings may help enhance our understanding of how PRF impacts basic physiological processes in bone and mineralized tissue.https://www.mdpi.com/2079-4983/14/10/503reviewosteoblastcell therapyPRFplatelet concentrates |
| spellingShingle | Renata de Lima Barbosa Emanuelle Stellet Lourenço Julya Vittoria de Azevedo dos Santos Neilane Rodrigues Santiago Rocha Carlos Fernando Mourão Gutemberg Gomes Alves The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence Journal of Functional Biomaterials review osteoblast cell therapy PRF platelet concentrates |
| title | The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence |
| title_full | The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence |
| title_fullStr | The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence |
| title_full_unstemmed | The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence |
| title_short | The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration—A Scoping Review of In Vitro Evidence |
| title_sort | effects of platelet rich fibrin in the behavior of mineralizing cells related to bone tissue regeneration a scoping review of in vitro evidence |
| topic | review osteoblast cell therapy PRF platelet concentrates |
| url | https://www.mdpi.com/2079-4983/14/10/503 |
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