EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS
Background: Alzheimer's disease (AD) is a neurodegenerative disorder marked by brain inflammation resulted in structural damage and brain dysfunction. Tumor necrosis factor α (TNFα) is a cytokine that plays an important role in inflammation. Dates fruit may help to fight oxidative stress an...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2021-12-01
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| Series: | Malang Neurology Journal |
| Subjects: | |
| Online Access: | https://mnj.ub.ac.id/index.php/mnj/article/view/547 |
| _version_ | 1797740423090798592 |
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| author | Elita Marintan Brian Wasita Adi Magna |
| author_facet | Elita Marintan Brian Wasita Adi Magna |
| author_sort | Elita Marintan |
| collection | DOAJ |
| description | Background: Alzheimer's disease (AD) is a neurodegenerative disorder marked by brain inflammation resulted in structural damage and brain dysfunction. Tumor necrosis factor α (TNFα) is a cytokine that plays an important role in inflammation. Dates fruit may help to fight oxidative stress and inflammation in the brain.
Objective: To determine the effect of date fruit extracts on blood TNFα levels and brain weight of alzheimer’s model rats.
Methods: This research is a laboratory experimental study by post-test only with control group design using alzheimer model rats. This study used 6 treatment groups with simple randomization. Each treatment group was represented by 8 Sprague Dawley rats. The normal control group (KN) was not induced by Hcy and was not given date palm extract, the negative control group (K-) was the Alzheimer's experimental rats which was not given the date palm extract, the positive group was the Alzheimer's experimental rats which was given the Donepezil (K+). Groups P1, P2, P3 were Alzheimer's experimental rats that were given date palm extract at a dose of 200, 400,800 mg / kgBW / day. The effect of date palm extract dosage on TNFα levels and brain weight were analyzed using the One Way Anova test followed by Tukey's post hoc test.
Results: The difference in TNFα levels between groups showed a significant difference (p = 0.00). Meanwhile there was no significant difference in brain weight among all groups (p > 0,05).Â
Conclusion: Date palm extract at doses of 200, 400, 800 mg / kgBW can decrease blood TNFα levels of Alzheimer’s model rats. |
| first_indexed | 2024-03-12T14:12:13Z |
| format | Article |
| id | doaj.art-040e397406e34ed5ac406df69f7a34db |
| institution | Directory Open Access Journal |
| issn | 2407-6724 2442-5001 |
| language | English |
| last_indexed | 2024-03-12T14:12:13Z |
| publishDate | 2021-12-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Malang Neurology Journal |
| spelling | doaj.art-040e397406e34ed5ac406df69f7a34db2023-08-21T05:47:48ZengUniversity of BrawijayaMalang Neurology Journal2407-67242442-50012021-12-0181252910.21776/ub.mnj.2022.008.01.6350EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATSElita Marintan0Brian Wasita1Adi Magna2Nutrition Science Study Program, Faculty of Postgraduate, Universitas Sebelas Maret, Surakarta, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, IndonesiaAnimal Science Department, Faculty of Agriculture, Universitas Sebelas Maret, Surakarta, IndonesiaBackground: Alzheimer's disease (AD) is a neurodegenerative disorder marked by brain inflammation resulted in structural damage and brain dysfunction. Tumor necrosis factor α (TNFα) is a cytokine that plays an important role in inflammation. Dates fruit may help to fight oxidative stress and inflammation in the brain. Objective: To determine the effect of date fruit extracts on blood TNFα levels and brain weight of alzheimer’s model rats. Methods: This research is a laboratory experimental study by post-test only with control group design using alzheimer model rats. This study used 6 treatment groups with simple randomization. Each treatment group was represented by 8 Sprague Dawley rats. The normal control group (KN) was not induced by Hcy and was not given date palm extract, the negative control group (K-) was the Alzheimer's experimental rats which was not given the date palm extract, the positive group was the Alzheimer's experimental rats which was given the Donepezil (K+). Groups P1, P2, P3 were Alzheimer's experimental rats that were given date palm extract at a dose of 200, 400,800 mg / kgBW / day. The effect of date palm extract dosage on TNFα levels and brain weight were analyzed using the One Way Anova test followed by Tukey's post hoc test. Results: The difference in TNFα levels between groups showed a significant difference (p = 0.00). Meanwhile there was no significant difference in brain weight among all groups (p > 0,05). Conclusion: Date palm extract at doses of 200, 400, 800 mg / kgBW can decrease blood TNFα levels of Alzheimer’s model rats.https://mnj.ub.ac.id/index.php/mnj/article/view/547alzheimer'stnfαdate palm extractbrain weightinflammation |
| spellingShingle | Elita Marintan Brian Wasita Adi Magna EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS Malang Neurology Journal alzheimer's tnfα date palm extract brain weight inflammation |
| title | EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS |
| title_full | EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS |
| title_fullStr | EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS |
| title_full_unstemmed | EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS |
| title_short | EFFECT OF DATE FRUIT (PHOENIX DACTYLIFERA L.) EXTRACT ON TNFα LEVELS AND BRAIN WEIGHT OF ALZHEIMER’S MODEL RATS |
| title_sort | effect of date fruit phoenix dactylifera l extract on tnfα levels and brain weight of alzheimer s model rats |
| topic | alzheimer's tnfα date palm extract brain weight inflammation |
| url | https://mnj.ub.ac.id/index.php/mnj/article/view/547 |
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