Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview
The characterization of the protein and lipid cargo of milk extracellular vesicles from different mammal species is crucial for understanding their biogenesis and biological functions, as well as for a comprehensive description of the nutritional aspects of animal milk for human diet. In fact, milk...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/2/401 |
| _version_ | 1797619808021250048 |
|---|---|
| author | Sandra Buratta Lorena Urbanelli Alessia Tognoloni Raffaella Latella Giada Cerrotti Carla Emiliani Elisabetta Chiaradia |
| author_facet | Sandra Buratta Lorena Urbanelli Alessia Tognoloni Raffaella Latella Giada Cerrotti Carla Emiliani Elisabetta Chiaradia |
| author_sort | Sandra Buratta |
| collection | DOAJ |
| description | The characterization of the protein and lipid cargo of milk extracellular vesicles from different mammal species is crucial for understanding their biogenesis and biological functions, as well as for a comprehensive description of the nutritional aspects of animal milk for human diet. In fact, milk EVs have been reported to possess relevant biological effects, but the molecules/biochemical pathways underlying these effects have been poorly investigated. The biochemical characterization is an important initial step for the potential therapeutic and diagnostic use of natural or modified milk EVs. The number of studies analysing the protein and lipid composition of milk EVs is limited compared to that investigating the nucleic acid cargo. Here, we revised the literature regarding the protein and lipid content of milk EVs. Until now, most investigations have shown that the biochemical cargo of EVs is different with respect to that of other milk fractions. In addition, even if these studies derived mostly from bovine and human milk EVs, comparison between milk EVs from different animal species and milk EVs biochemical composition changes due to different factors including lactation stages and health status is also beginning to be reported. |
| first_indexed | 2024-03-11T08:32:06Z |
| format | Article |
| id | doaj.art-040fd0edc7724917ad85d17ae6e50a09 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-040fd0edc7724917ad85d17ae6e50a092023-11-16T21:40:45ZengMDPI AGLife2075-17292023-02-0113240110.3390/life13020401Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative OverviewSandra Buratta0Lorena Urbanelli1Alessia Tognoloni2Raffaella Latella3Giada Cerrotti4Carla Emiliani5Elisabetta Chiaradia6Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, ItalyDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyThe characterization of the protein and lipid cargo of milk extracellular vesicles from different mammal species is crucial for understanding their biogenesis and biological functions, as well as for a comprehensive description of the nutritional aspects of animal milk for human diet. In fact, milk EVs have been reported to possess relevant biological effects, but the molecules/biochemical pathways underlying these effects have been poorly investigated. The biochemical characterization is an important initial step for the potential therapeutic and diagnostic use of natural or modified milk EVs. The number of studies analysing the protein and lipid composition of milk EVs is limited compared to that investigating the nucleic acid cargo. Here, we revised the literature regarding the protein and lipid content of milk EVs. Until now, most investigations have shown that the biochemical cargo of EVs is different with respect to that of other milk fractions. In addition, even if these studies derived mostly from bovine and human milk EVs, comparison between milk EVs from different animal species and milk EVs biochemical composition changes due to different factors including lactation stages and health status is also beginning to be reported.https://www.mdpi.com/2075-1729/13/2/401extracellular vesicleexosomemilkproteomicslipidomics |
| spellingShingle | Sandra Buratta Lorena Urbanelli Alessia Tognoloni Raffaella Latella Giada Cerrotti Carla Emiliani Elisabetta Chiaradia Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview Life extracellular vesicle exosome milk proteomics lipidomics |
| title | Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview |
| title_full | Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview |
| title_fullStr | Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview |
| title_full_unstemmed | Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview |
| title_short | Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview |
| title_sort | protein and lipid content of milk extracellular vesicles a comparative overview |
| topic | extracellular vesicle exosome milk proteomics lipidomics |
| url | https://www.mdpi.com/2075-1729/13/2/401 |
| work_keys_str_mv | AT sandraburatta proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview AT lorenaurbanelli proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview AT alessiatognoloni proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview AT raffaellalatella proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview AT giadacerrotti proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview AT carlaemiliani proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview AT elisabettachiaradia proteinandlipidcontentofmilkextracellularvesiclesacomparativeoverview |