Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population
Qianqian Yao,1,* Kexin Jiang,1,* Fei Lin,2 Tao Zhu,3 Nazeer Hussain Khan,1,4 Enshe Jiang1,4 1Institute of Nursing and Health, Henan University, Kaifeng, People’s Republic of China; 2School of Medicine, Shangqiu Institute of Technology, Shangqiu, People’s Republic of China; 3Departmen...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-05-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/pathophysiological-association-of-alzheimers-disease-and-hypertension--peer-reviewed-fulltext-article-CIA |
| _version_ | 1827952439969447936 |
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| author | Yao Q Jiang K Lin F Zhu T Khan NH Jiang E |
| author_facet | Yao Q Jiang K Lin F Zhu T Khan NH Jiang E |
| author_sort | Yao Q |
| collection | DOAJ |
| description | Qianqian Yao,1,* Kexin Jiang,1,* Fei Lin,2 Tao Zhu,3 Nazeer Hussain Khan,1,4 Enshe Jiang1,4 1Institute of Nursing and Health, Henan University, Kaifeng, People’s Republic of China; 2School of Medicine, Shangqiu Institute of Technology, Shangqiu, People’s Republic of China; 3Department of Geriatrics, Kaifeng Traditional Chinese Medicine Hospital, Kaifeng, People’s Republic of China; 4Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Enshe Jiang, Email esjiang@gmail.comAbstract: Alzheimer’s disease (AD), the most common cause of dementia and the fifth leading cause of death in the adult population has a complex pathophysiological link with hypertension (HTN). A growing volume of published literature on a parallel elevation of blood pressure (BP), amyloid plaques, and neurofibrillary tangles formation in post-middle of human brain cells has developed new, widely accepting foundations on this association. In particular, HTN in elderly life mediates cerebral blood flow dysfunction, neuronal dysfunction, and significant decline in cognitive impairment, primarily in the late-life populace, governing the onset of AD. Thus, HTN is an established risk factor for AD. Considering the impact of AD, 1.89 million deaths annually, and the failure of palliative therapies to cure AD, the scientific research community is looking to adopt integrated approaches to target early modified risk factors like HTN to reduce AD burden. The current review highlights the significance and impact of HTN-based prevention in lowering the AD burden in the elderly by providing a comprehensive overview of the physiological relationship between AD and HTN with an in-detail explanation of the role and applications of pathological biomarkers in this clinical association. The review will gain worth in presenting new insights and providing inclusive discussion on the correlation between HTN and cognitive impairment. It will increase across a wider scientific audience to expand understanding of this pathophysiological association.Keywords: Alzheimer’s disease, hypertension, elderly population, clinical biomarkers |
| first_indexed | 2024-04-09T13:57:23Z |
| format | Article |
| id | doaj.art-04107b58335848ea9ad4a1906c48f3eb |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-04-09T13:57:23Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-04107b58335848ea9ad4a1906c48f3eb2023-05-07T16:04:05ZengDove Medical PressClinical Interventions in Aging1178-19982023-05-01Volume 1871372883521Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly PopulationYao QJiang KLin FZhu TKhan NHJiang EQianqian Yao,1,* Kexin Jiang,1,* Fei Lin,2 Tao Zhu,3 Nazeer Hussain Khan,1,4 Enshe Jiang1,4 1Institute of Nursing and Health, Henan University, Kaifeng, People’s Republic of China; 2School of Medicine, Shangqiu Institute of Technology, Shangqiu, People’s Republic of China; 3Department of Geriatrics, Kaifeng Traditional Chinese Medicine Hospital, Kaifeng, People’s Republic of China; 4Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Enshe Jiang, Email esjiang@gmail.comAbstract: Alzheimer’s disease (AD), the most common cause of dementia and the fifth leading cause of death in the adult population has a complex pathophysiological link with hypertension (HTN). A growing volume of published literature on a parallel elevation of blood pressure (BP), amyloid plaques, and neurofibrillary tangles formation in post-middle of human brain cells has developed new, widely accepting foundations on this association. In particular, HTN in elderly life mediates cerebral blood flow dysfunction, neuronal dysfunction, and significant decline in cognitive impairment, primarily in the late-life populace, governing the onset of AD. Thus, HTN is an established risk factor for AD. Considering the impact of AD, 1.89 million deaths annually, and the failure of palliative therapies to cure AD, the scientific research community is looking to adopt integrated approaches to target early modified risk factors like HTN to reduce AD burden. The current review highlights the significance and impact of HTN-based prevention in lowering the AD burden in the elderly by providing a comprehensive overview of the physiological relationship between AD and HTN with an in-detail explanation of the role and applications of pathological biomarkers in this clinical association. The review will gain worth in presenting new insights and providing inclusive discussion on the correlation between HTN and cognitive impairment. It will increase across a wider scientific audience to expand understanding of this pathophysiological association.Keywords: Alzheimer’s disease, hypertension, elderly population, clinical biomarkershttps://www.dovepress.com/pathophysiological-association-of-alzheimers-disease-and-hypertension--peer-reviewed-fulltext-article-CIAalzheimer's diseasehypertensionelderly populationclinical biomarkers |
| spellingShingle | Yao Q Jiang K Lin F Zhu T Khan NH Jiang E Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population Clinical Interventions in Aging alzheimer's disease hypertension elderly population clinical biomarkers |
| title | Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population |
| title_full | Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population |
| title_fullStr | Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population |
| title_full_unstemmed | Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population |
| title_short | Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population |
| title_sort | pathophysiological association of alzheimer rsquo s disease and hypertension a clinical concern for elderly population |
| topic | alzheimer's disease hypertension elderly population clinical biomarkers |
| url | https://www.dovepress.com/pathophysiological-association-of-alzheimers-disease-and-hypertension--peer-reviewed-fulltext-article-CIA |
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