LOXL2 in Cancer: A Two-Decade Perspective
Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003, LOXL2 was first identified as a promoter of tumour progression and, over the course of two decades, numerous studies have firml...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14405 |
| _version_ | 1797579556060659712 |
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| author | Amparo Cano Pilar Eraso María J. Mazón Francisco Portillo |
| author_facet | Amparo Cano Pilar Eraso María J. Mazón Francisco Portillo |
| author_sort | Amparo Cano |
| collection | DOAJ |
| description | Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003, LOXL2 was first identified as a promoter of tumour progression and, over the course of two decades, numerous studies have firmly established its involvement in multiple cancers. Extensive research with large cohorts of human tumour samples has demonstrated that dysregulated LOXL2 expression is strongly associated with poor prognosis in patients. Moreover, investigations have revealed the association of LOXL2 with various targets affecting diverse aspects of tumour progression. Additionally, the discovery of a complex network of signalling factors acting at the transcriptional, post-transcriptional, and post-translational levels has provided insights into the mechanisms underlying the aberrant expression of LOXL2 in tumours. Furthermore, the development of genetically modified mouse models with silenced or overexpressed LOXL2 has enabled in-depth exploration of its in vivo role in various cancer models. Given the significant role of LOXL2 in numerous cancers, extensive efforts are underway to identify specific inhibitors that could potentially improve patient prognosis. In this review, we aim to provide a comprehensive overview of two decades of research on the role of LOXL2 in cancer. |
| first_indexed | 2024-03-10T22:38:47Z |
| format | Article |
| id | doaj.art-04128e0ae3d342598d65a47fc995dced |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:38:47Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-04128e0ae3d342598d65a47fc995dced2023-11-19T11:12:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181440510.3390/ijms241814405LOXL2 in Cancer: A Two-Decade PerspectiveAmparo Cano0Pilar Eraso1María J. Mazón2Francisco Portillo3Departamento de Bioquímica UAM, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, SpainDepartamento de Bioquímica UAM, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, SpainDepartamento de Bioquímica UAM, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, SpainDepartamento de Bioquímica UAM, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, SpainLysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003, LOXL2 was first identified as a promoter of tumour progression and, over the course of two decades, numerous studies have firmly established its involvement in multiple cancers. Extensive research with large cohorts of human tumour samples has demonstrated that dysregulated LOXL2 expression is strongly associated with poor prognosis in patients. Moreover, investigations have revealed the association of LOXL2 with various targets affecting diverse aspects of tumour progression. Additionally, the discovery of a complex network of signalling factors acting at the transcriptional, post-transcriptional, and post-translational levels has provided insights into the mechanisms underlying the aberrant expression of LOXL2 in tumours. Furthermore, the development of genetically modified mouse models with silenced or overexpressed LOXL2 has enabled in-depth exploration of its in vivo role in various cancer models. Given the significant role of LOXL2 in numerous cancers, extensive efforts are underway to identify specific inhibitors that could potentially improve patient prognosis. In this review, we aim to provide a comprehensive overview of two decades of research on the role of LOXL2 in cancer.https://www.mdpi.com/1422-0067/24/18/14405LOXL2human tumour sampleregulationtargetsmouse modelstumour progression |
| spellingShingle | Amparo Cano Pilar Eraso María J. Mazón Francisco Portillo LOXL2 in Cancer: A Two-Decade Perspective International Journal of Molecular Sciences LOXL2 human tumour sample regulation targets mouse models tumour progression |
| title | LOXL2 in Cancer: A Two-Decade Perspective |
| title_full | LOXL2 in Cancer: A Two-Decade Perspective |
| title_fullStr | LOXL2 in Cancer: A Two-Decade Perspective |
| title_full_unstemmed | LOXL2 in Cancer: A Two-Decade Perspective |
| title_short | LOXL2 in Cancer: A Two-Decade Perspective |
| title_sort | loxl2 in cancer a two decade perspective |
| topic | LOXL2 human tumour sample regulation targets mouse models tumour progression |
| url | https://www.mdpi.com/1422-0067/24/18/14405 |
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