Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury
The debilitating effect of traumatic brain injury (TBI) extends years after the initial injury and hampers the recovery process and quality of life. In this study, we explore the functional reorganization of the default mode network (DMN) of those affected with non-severe TBI. Traumatic brain injury...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.833320/full |
| _version_ | 1818393663810568192 |
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| author | Muhammad Riddha Abdul Rahman Muhammad Riddha Abdul Rahman Muhammad Riddha Abdul Rahman Aini Ismafairus Abd Hamid Aini Ismafairus Abd Hamid Aini Ismafairus Abd Hamid Nor Azila Noh Hazim Omar Hazim Omar Hazim Omar Wen Jia Chai Wen Jia Chai Zamzuri Idris Zamzuri Idris Zamzuri Idris Asma Hayati Ahmad Diana Noma Fitzrol Diana Noma Fitzrol Diana Noma Fitzrol Ab. Rahman Izaini Ghani Ab. Ghani Ab. Rahman Izaini Ghani Ab. Ghani Ab. Rahman Izaini Ghani Ab. Ghani Wan Nor Azlen Wan Mohamad Wan Nor Azlen Wan Mohamad Wan Nor Azlen Wan Mohamad Mohamed Faiz Mohamed Mustafar Mohamed Faiz Mohamed Mustafar Mohamed Faiz Mohamed Mustafar Muhammad Hafiz Hanafi Muhammad Hafiz Hanafi Muhammad Hafiz Hanafi Mohamed Faruque Reza Mohamed Faruque Reza Mohamed Faruque Reza Hafidah Umar Hafidah Umar Hafidah Umar Mohd Faizal Mohd Zulkifly Mohd Faizal Mohd Zulkifly Mohd Faizal Mohd Zulkifly Song Yee Ang Song Yee Ang Song Yee Ang Zaitun Zakaria Zaitun Zakaria Zaitun Zakaria Kamarul Imran Musa Azizah Othman Zunaina Embong Nur Asma Sapiai Regunath Kandasamy Haidi Ibrahim Mohd Zaid Abdullah Kannapha Amaruchkul Pedro Valdes-Sosa Pedro Valdes-Sosa Maria Luisa-Bringas Maria Luisa-Bringas Bharat Biswal Jitkomut Songsiri Hamwira Sakti Yaacob Putra Sumari Paramjit Singh Jamir Singh Azlinda Azman Jafri Malin Abdullah Jafri Malin Abdullah Jafri Malin Abdullah |
| author_facet | Muhammad Riddha Abdul Rahman Muhammad Riddha Abdul Rahman Muhammad Riddha Abdul Rahman Aini Ismafairus Abd Hamid Aini Ismafairus Abd Hamid Aini Ismafairus Abd Hamid Nor Azila Noh Hazim Omar Hazim Omar Hazim Omar Wen Jia Chai Wen Jia Chai Zamzuri Idris Zamzuri Idris Zamzuri Idris Asma Hayati Ahmad Diana Noma Fitzrol Diana Noma Fitzrol Diana Noma Fitzrol Ab. Rahman Izaini Ghani Ab. Ghani Ab. Rahman Izaini Ghani Ab. Ghani Ab. Rahman Izaini Ghani Ab. Ghani Wan Nor Azlen Wan Mohamad Wan Nor Azlen Wan Mohamad Wan Nor Azlen Wan Mohamad Mohamed Faiz Mohamed Mustafar Mohamed Faiz Mohamed Mustafar Mohamed Faiz Mohamed Mustafar Muhammad Hafiz Hanafi Muhammad Hafiz Hanafi Muhammad Hafiz Hanafi Mohamed Faruque Reza Mohamed Faruque Reza Mohamed Faruque Reza Hafidah Umar Hafidah Umar Hafidah Umar Mohd Faizal Mohd Zulkifly Mohd Faizal Mohd Zulkifly Mohd Faizal Mohd Zulkifly Song Yee Ang Song Yee Ang Song Yee Ang Zaitun Zakaria Zaitun Zakaria Zaitun Zakaria Kamarul Imran Musa Azizah Othman Zunaina Embong Nur Asma Sapiai Regunath Kandasamy Haidi Ibrahim Mohd Zaid Abdullah Kannapha Amaruchkul Pedro Valdes-Sosa Pedro Valdes-Sosa Maria Luisa-Bringas Maria Luisa-Bringas Bharat Biswal Jitkomut Songsiri Hamwira Sakti Yaacob Putra Sumari Paramjit Singh Jamir Singh Azlinda Azman Jafri Malin Abdullah Jafri Malin Abdullah Jafri Malin Abdullah |
| author_sort | Muhammad Riddha Abdul Rahman |
| collection | DOAJ |
| description | The debilitating effect of traumatic brain injury (TBI) extends years after the initial injury and hampers the recovery process and quality of life. In this study, we explore the functional reorganization of the default mode network (DMN) of those affected with non-severe TBI. Traumatic brain injury (TBI) is a wide-spectrum disease that has heterogeneous effects on its victims and impacts everyday functioning. The functional disruption of the default mode network (DMN) after TBI has been established, but its link to causal effective connectivity remains to be explored. This study investigated the differences in the DMN between healthy participants and mild and moderate TBI, in terms of functional and effective connectivity using resting-state functional magnetic resonance imaging (fMRI). Nineteen non-severe TBI (mean age 30.84 ± 14.56) and twenty-two healthy (HC; mean age 27.23 ± 6.32) participants were recruited for this study. Resting-state fMRI data were obtained at the subacute phase (mean days 40.63 ± 10.14) and analyzed for functional activation and connectivity, independent component analysis, and effective connectivity within and between the DMN. Neuropsychological tests were also performed to assess the cognitive and memory domains. Compared to the HC, the TBI group exhibited lower activation in the thalamus, as well as significant functional hypoconnectivity between DMN and LN. Within the DMN nodes, decreased activations were detected in the left inferior parietal lobule, precuneus, and right superior frontal gyrus. Altered effective connectivities were also observed in the TBI group and were linked to the diminished activation in the left parietal region and precuneus. With regard to intra-DMN connectivity within the TBI group, positive correlations were found in verbal and visual memory with the language network, while a negative correlation was found in the cognitive domain with the visual network. Our results suggested that aberrant activities and functional connectivities within the DMN and with other RSNs were accompanied by the altered effective connectivities in the TBI group. These alterations were associated with impaired cognitive and memory domains in the TBI group, in particular within the language domain. These findings may provide insight for future TBI observational and interventional research. |
| first_indexed | 2024-12-14T05:48:54Z |
| format | Article |
| id | doaj.art-0412bc0d195d402ca49d752409470607 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T05:48:54Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0412bc0d195d402ca49d7524094706072022-12-21T23:14:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-03-011610.3389/fnins.2022.833320833320Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain InjuryMuhammad Riddha Abdul Rahman0Muhammad Riddha Abdul Rahman1Muhammad Riddha Abdul Rahman2Aini Ismafairus Abd Hamid3Aini Ismafairus Abd Hamid4Aini Ismafairus Abd Hamid5Nor Azila Noh6Hazim Omar7Hazim Omar8Hazim Omar9Wen Jia Chai10Wen Jia Chai11Zamzuri Idris12Zamzuri Idris13Zamzuri Idris14Asma Hayati Ahmad15Diana Noma Fitzrol16Diana Noma Fitzrol17Diana Noma Fitzrol18Ab. Rahman Izaini Ghani Ab. Ghani19Ab. Rahman Izaini Ghani Ab. Ghani20Ab. Rahman Izaini Ghani Ab. Ghani21Wan Nor Azlen Wan Mohamad22Wan Nor Azlen Wan Mohamad23Wan Nor Azlen Wan Mohamad24Mohamed Faiz Mohamed Mustafar25Mohamed Faiz Mohamed Mustafar26Mohamed Faiz Mohamed Mustafar27Muhammad Hafiz Hanafi28Muhammad Hafiz Hanafi29Muhammad Hafiz Hanafi30Mohamed Faruque Reza31Mohamed Faruque Reza32Mohamed Faruque Reza33Hafidah Umar34Hafidah Umar35Hafidah Umar36Mohd Faizal Mohd Zulkifly37Mohd Faizal Mohd Zulkifly38Mohd Faizal Mohd Zulkifly39Song Yee Ang40Song Yee Ang41Song Yee Ang42Zaitun Zakaria43Zaitun Zakaria44Zaitun Zakaria45Kamarul Imran Musa46Azizah Othman47Zunaina Embong48Nur Asma Sapiai49Regunath Kandasamy50Haidi Ibrahim51Mohd Zaid Abdullah52Kannapha Amaruchkul53Pedro Valdes-Sosa54Pedro Valdes-Sosa55Maria Luisa-Bringas56Maria Luisa-Bringas57Bharat Biswal58Jitkomut Songsiri59Hamwira Sakti Yaacob60Putra Sumari61Paramjit Singh Jamir Singh62Azlinda Azman63Jafri Malin Abdullah64Jafri Malin Abdullah65Jafri Malin Abdullah66Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaSchool of Medical Imaging, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaFaculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaDepartment of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia0Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia1Gleneagles Hospital Kuala Lumpur, Kuala Lumpur, Malaysia2School of Electrical and Electronic Engineering, Universiti Sains Malaysia, Nibong Tebal, Malaysia2School of Electrical and Electronic Engineering, Universiti Sains Malaysia, Nibong Tebal, Malaysia3Graduate School of Applied Statistics, National Institute of Development Administration (NIDA), Bangkok, Thailand4The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China5The Cuban Neurosciences Center, Havana, Cuba4The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China5The Cuban Neurosciences Center, Havana, Cuba6Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States7EE410 Control Systems Laboratory, Department of Electrical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand8Department of Computer Science, Kulliyah of Information and Communication Technology, International Islamic University Malaysia, Kuala Lumpur, Malaysia9School of Computer Sciences, Universiti Sains Malaysia, Gelugor, Malaysia0School of Social Sciences, Universiti Sains Malaysia, Gelugor, Malaysia0School of Social Sciences, Universiti Sains Malaysia, Gelugor, MalaysiaDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaBrain and Behavior Cluster, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MalaysiaHospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, MalaysiaThe debilitating effect of traumatic brain injury (TBI) extends years after the initial injury and hampers the recovery process and quality of life. In this study, we explore the functional reorganization of the default mode network (DMN) of those affected with non-severe TBI. Traumatic brain injury (TBI) is a wide-spectrum disease that has heterogeneous effects on its victims and impacts everyday functioning. The functional disruption of the default mode network (DMN) after TBI has been established, but its link to causal effective connectivity remains to be explored. This study investigated the differences in the DMN between healthy participants and mild and moderate TBI, in terms of functional and effective connectivity using resting-state functional magnetic resonance imaging (fMRI). Nineteen non-severe TBI (mean age 30.84 ± 14.56) and twenty-two healthy (HC; mean age 27.23 ± 6.32) participants were recruited for this study. Resting-state fMRI data were obtained at the subacute phase (mean days 40.63 ± 10.14) and analyzed for functional activation and connectivity, independent component analysis, and effective connectivity within and between the DMN. Neuropsychological tests were also performed to assess the cognitive and memory domains. Compared to the HC, the TBI group exhibited lower activation in the thalamus, as well as significant functional hypoconnectivity between DMN and LN. Within the DMN nodes, decreased activations were detected in the left inferior parietal lobule, precuneus, and right superior frontal gyrus. Altered effective connectivities were also observed in the TBI group and were linked to the diminished activation in the left parietal region and precuneus. With regard to intra-DMN connectivity within the TBI group, positive correlations were found in verbal and visual memory with the language network, while a negative correlation was found in the cognitive domain with the visual network. Our results suggested that aberrant activities and functional connectivities within the DMN and with other RSNs were accompanied by the altered effective connectivities in the TBI group. These alterations were associated with impaired cognitive and memory domains in the TBI group, in particular within the language domain. These findings may provide insight for future TBI observational and interventional research.https://www.frontiersin.org/articles/10.3389/fnins.2022.833320/fulldefault mode networktraumatic brain injuryfunctional connectivityeffective connectivityneuropsychology |
| spellingShingle | Muhammad Riddha Abdul Rahman Muhammad Riddha Abdul Rahman Muhammad Riddha Abdul Rahman Aini Ismafairus Abd Hamid Aini Ismafairus Abd Hamid Aini Ismafairus Abd Hamid Nor Azila Noh Hazim Omar Hazim Omar Hazim Omar Wen Jia Chai Wen Jia Chai Zamzuri Idris Zamzuri Idris Zamzuri Idris Asma Hayati Ahmad Diana Noma Fitzrol Diana Noma Fitzrol Diana Noma Fitzrol Ab. Rahman Izaini Ghani Ab. Ghani Ab. Rahman Izaini Ghani Ab. Ghani Ab. Rahman Izaini Ghani Ab. Ghani Wan Nor Azlen Wan Mohamad Wan Nor Azlen Wan Mohamad Wan Nor Azlen Wan Mohamad Mohamed Faiz Mohamed Mustafar Mohamed Faiz Mohamed Mustafar Mohamed Faiz Mohamed Mustafar Muhammad Hafiz Hanafi Muhammad Hafiz Hanafi Muhammad Hafiz Hanafi Mohamed Faruque Reza Mohamed Faruque Reza Mohamed Faruque Reza Hafidah Umar Hafidah Umar Hafidah Umar Mohd Faizal Mohd Zulkifly Mohd Faizal Mohd Zulkifly Mohd Faizal Mohd Zulkifly Song Yee Ang Song Yee Ang Song Yee Ang Zaitun Zakaria Zaitun Zakaria Zaitun Zakaria Kamarul Imran Musa Azizah Othman Zunaina Embong Nur Asma Sapiai Regunath Kandasamy Haidi Ibrahim Mohd Zaid Abdullah Kannapha Amaruchkul Pedro Valdes-Sosa Pedro Valdes-Sosa Maria Luisa-Bringas Maria Luisa-Bringas Bharat Biswal Jitkomut Songsiri Hamwira Sakti Yaacob Putra Sumari Paramjit Singh Jamir Singh Azlinda Azman Jafri Malin Abdullah Jafri Malin Abdullah Jafri Malin Abdullah Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury Frontiers in Neuroscience default mode network traumatic brain injury functional connectivity effective connectivity neuropsychology |
| title | Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury |
| title_full | Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury |
| title_fullStr | Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury |
| title_full_unstemmed | Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury |
| title_short | Alteration in the Functional Organization of the Default Mode Network Following Closed Non-severe Traumatic Brain Injury |
| title_sort | alteration in the functional organization of the default mode network following closed non severe traumatic brain injury |
| topic | default mode network traumatic brain injury functional connectivity effective connectivity neuropsychology |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.833320/full |
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