G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment

G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment

Abstract Objectives Recombinant granulocyte colony‐stimulating factor (G‐CSF) is frequently administered to patients with cancer to enhance granulocyte recovery post‐chemotherapy. Clinical trials have also used G‐CSF to modulate myeloid cell function in pregnancy and inflammatory diseases. Although...

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Bibliographic Details
Main Authors: Ebtehag Maneta, Livingstone Fultang, Jemma Taylor, Matthew Pugh, William Jenkinson, Graham Anderson, Arri Coomarasamy, Mark D Kilby, David M Lissauer, Francis Mussai, Carmela De Santo
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
cancer
CD15+CD14+
G‐CSF
MDSC
placenta
Online Access:https://doi.org/10.1002/cti2.1395

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