Clinicopathological characteristics and survival of spinal cord astrocytomas
Abstract Background Due to their rarity, the clinicopathological characteristics and prognostic factors of spinal cord gliomas are still unclear. Here, we aimed to clarify these issues in a cohort of 108 spinal cord astrocytomas. Methods We characterized the clinicopathological characteristics, incl...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3364 |
| _version_ | 1797839368399880192 |
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| author | Yao‐Wu Zhang Rui‐Chao Chai Ren Cao Wen‐Ju Jiang Wei‐Hao Liu Yu‐Lun Xu Jun Yang Yong‐Zhi Wang Wen‐Qing Jia |
| author_facet | Yao‐Wu Zhang Rui‐Chao Chai Ren Cao Wen‐Ju Jiang Wei‐Hao Liu Yu‐Lun Xu Jun Yang Yong‐Zhi Wang Wen‐Qing Jia |
| author_sort | Yao‐Wu Zhang |
| collection | DOAJ |
| description | Abstract Background Due to their rarity, the clinicopathological characteristics and prognostic factors of spinal cord gliomas are still unclear. Here, we aimed to clarify these issues in a cohort of 108 spinal cord astrocytomas. Methods We characterized the clinicopathological characteristics, including 2016 World Health Organization (WHO) grade, age, sex, location, segment length, resection, pre‐ and postsurgery, Modified McCormick Scale (MMS), radio‐ and chemotherapy, and Ki‐67 and H3 K27M mutations, in 108 spinal cord astrocytomas through heatmaps. The Cox regression analysis and Kaplan‐Meier curves were used to study the prognostic value of these clinicopathological features. Results There are a total 38 H3 K27M‐mutant tumors, including 31 cases with histological grade II/III tumors. The age of low‐grade astrocytoma patients (WHO grade I/II, n = 54) was significantly younger (27.0 vs 35.5 years, P = .001) than those with high‐grade tumors (WHO grade III/IV, n = 54). All patients underwent surgical resection with neurophysiological monitoring, and the surgery did not result in significant changes in MMS. The presurgery MMS was associated with overall survival in the high‐grade subgroup (P = .008) but not in the low‐grade subgroup (P = .312). While, the high content of resection improved the survival of only patients with low‐grade astrocytomas (P = .016) but not those with high‐grade astrocytomas (P = .475). Both the low‐grade and high‐grade astrocytomas had no obvious benefit from neither adjuvant chemotherapy nor radiotherapy (all P > .05). Conclusions We characterized the clinicopathological characteristics and their prognostic values in 108 spinal cord astrocytomas, which could help with evidence‐based management of spinal cord astrocytomas. |
| first_indexed | 2024-04-09T15:56:53Z |
| format | Article |
| id | doaj.art-041549128ed246a3a5d9e1e6b07a83db |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T15:56:53Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-041549128ed246a3a5d9e1e6b07a83db2023-04-25T14:00:49ZengWileyCancer Medicine2045-76342020-10-019196996700610.1002/cam4.3364Clinicopathological characteristics and survival of spinal cord astrocytomasYao‐Wu Zhang0Rui‐Chao Chai1Ren Cao2Wen‐Ju Jiang3Wei‐Hao Liu4Yu‐Lun Xu5Jun Yang6Yong‐Zhi Wang7Wen‐Qing Jia8Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaChina National Clinical Research Center for Neurological Diseases Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaAbstract Background Due to their rarity, the clinicopathological characteristics and prognostic factors of spinal cord gliomas are still unclear. Here, we aimed to clarify these issues in a cohort of 108 spinal cord astrocytomas. Methods We characterized the clinicopathological characteristics, including 2016 World Health Organization (WHO) grade, age, sex, location, segment length, resection, pre‐ and postsurgery, Modified McCormick Scale (MMS), radio‐ and chemotherapy, and Ki‐67 and H3 K27M mutations, in 108 spinal cord astrocytomas through heatmaps. The Cox regression analysis and Kaplan‐Meier curves were used to study the prognostic value of these clinicopathological features. Results There are a total 38 H3 K27M‐mutant tumors, including 31 cases with histological grade II/III tumors. The age of low‐grade astrocytoma patients (WHO grade I/II, n = 54) was significantly younger (27.0 vs 35.5 years, P = .001) than those with high‐grade tumors (WHO grade III/IV, n = 54). All patients underwent surgical resection with neurophysiological monitoring, and the surgery did not result in significant changes in MMS. The presurgery MMS was associated with overall survival in the high‐grade subgroup (P = .008) but not in the low‐grade subgroup (P = .312). While, the high content of resection improved the survival of only patients with low‐grade astrocytomas (P = .016) but not those with high‐grade astrocytomas (P = .475). Both the low‐grade and high‐grade astrocytomas had no obvious benefit from neither adjuvant chemotherapy nor radiotherapy (all P > .05). Conclusions We characterized the clinicopathological characteristics and their prognostic values in 108 spinal cord astrocytomas, which could help with evidence‐based management of spinal cord astrocytomas.https://doi.org/10.1002/cam4.3364astrocytomaclinicopathological featureH3 K27Mspinal cord tumorsurvival |
| spellingShingle | Yao‐Wu Zhang Rui‐Chao Chai Ren Cao Wen‐Ju Jiang Wei‐Hao Liu Yu‐Lun Xu Jun Yang Yong‐Zhi Wang Wen‐Qing Jia Clinicopathological characteristics and survival of spinal cord astrocytomas Cancer Medicine astrocytoma clinicopathological feature H3 K27M spinal cord tumor survival |
| title | Clinicopathological characteristics and survival of spinal cord astrocytomas |
| title_full | Clinicopathological characteristics and survival of spinal cord astrocytomas |
| title_fullStr | Clinicopathological characteristics and survival of spinal cord astrocytomas |
| title_full_unstemmed | Clinicopathological characteristics and survival of spinal cord astrocytomas |
| title_short | Clinicopathological characteristics and survival of spinal cord astrocytomas |
| title_sort | clinicopathological characteristics and survival of spinal cord astrocytomas |
| topic | astrocytoma clinicopathological feature H3 K27M spinal cord tumor survival |
| url | https://doi.org/10.1002/cam4.3364 |
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