A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy
Background: Hepatitis B infection is a global public health problem. Chronic hepatitis B (CHB) infection leads to complications such as cirrhosis, liver failure, and hepatocellular carcinoma. Effective antiviral therapy significantly improves the stages of fibrosis in these patients. Hence, the live...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2024-02-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/59316 |
| _version_ | 1797333785340018688 |
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| author | Avick Nag Saubhik Ghosh Souvik Sarkar Soumya Sarathi Enamul Hossain Sanjay Kumar Mandal |
| author_facet | Avick Nag Saubhik Ghosh Souvik Sarkar Soumya Sarathi Enamul Hossain Sanjay Kumar Mandal |
| author_sort | Avick Nag |
| collection | DOAJ |
| description | Background: Hepatitis B infection is a global public health problem. Chronic hepatitis B (CHB) infection leads to complications such as cirrhosis, liver failure, and hepatocellular carcinoma. Effective antiviral therapy significantly improves the stages of fibrosis in these patients. Hence, the liver stiffness measurement using transient elastography (Fibroscan) in CHB patients undergoing treatment is important to evaluate the effectiveness of the therapy and to predict the prognosis.
Aims and Objectives: To see the outcome of Hepatic Fibrosis by non-invasive measurement in CHB patients after 6 months of oral anti-viral therapy.
Materials and Methods: Seventy new CHB patients are included in a prospective hospital-based study and at the end of 6 months 53 patients were analysed.
Results: Our study showed a significant statistical reduction in Liver Fibrosis as well as improvement of serological and biochemical parameters in CHB patients.
Conclusion: There is liver fibrosis reversal in CHB patients after 6 months of anti-viral therapy and Fibroscan helps not only as a marker for initiation of treatment depending on the degree of fibrosis but also indicates the response or progression of the disease. |
| first_indexed | 2024-03-08T08:10:09Z |
| format | Article |
| id | doaj.art-04160b6ba8cc477682018cb352626699 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-08T08:10:09Z |
| publishDate | 2024-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-04160b6ba8cc477682018cb3526266992024-02-02T08:51:39ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762024-02-0115298103https://doi.org/10.3126/ajms.v15i2.59316A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapyAvick Nag 0https://orcid.org/0009-0004-7429-7414Saubhik Ghosh 1https://orcid.org/0009-0009-6504-0744Souvik Sarkar 2https://orcid.org/0000-0002-0662-6333Soumya Sarathi 3https://orcid.org/0000-0002-4838-7780Enamul Hossain 4https://orcid.org/0000-0002-6283-1665Sanjay Kumar Mandal 5https://orcid.org/0000-0002-2925-056XResident Medical Officer, Department of Medicine, Medical College and Hospital, Kolkata, West Bengal, India Associate Professor, Department of Medical Gastroenterology, Medical College and Hospital, Kolkata, West Bengal, India Senior Resident, Department of General Medicine, Medical College and Hospital, Kolkata, West Bengal, India Mondal Professor, Department of General Medicine, Medical College and Hospital, Kolkata, West Bengal, India Senior Resident, Department of General Medicine, Medical College and Hospital, Kolkata, West Bengal, India Professor, Department of General Medicine, Medical College and Hospital, Kolkata, West Bengal, India Background: Hepatitis B infection is a global public health problem. Chronic hepatitis B (CHB) infection leads to complications such as cirrhosis, liver failure, and hepatocellular carcinoma. Effective antiviral therapy significantly improves the stages of fibrosis in these patients. Hence, the liver stiffness measurement using transient elastography (Fibroscan) in CHB patients undergoing treatment is important to evaluate the effectiveness of the therapy and to predict the prognosis. Aims and Objectives: To see the outcome of Hepatic Fibrosis by non-invasive measurement in CHB patients after 6 months of oral anti-viral therapy. Materials and Methods: Seventy new CHB patients are included in a prospective hospital-based study and at the end of 6 months 53 patients were analysed. Results: Our study showed a significant statistical reduction in Liver Fibrosis as well as improvement of serological and biochemical parameters in CHB patients. Conclusion: There is liver fibrosis reversal in CHB patients after 6 months of anti-viral therapy and Fibroscan helps not only as a marker for initiation of treatment depending on the degree of fibrosis but also indicates the response or progression of the disease.https://www.nepjol.info/index.php/AJMS/article/view/59316chronic hepatitis b; hepatitis b virus; hepatic fibrosis; fibroscan |
| spellingShingle | Avick Nag Saubhik Ghosh Souvik Sarkar Soumya Sarathi Enamul Hossain Sanjay Kumar Mandal A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy Asian Journal of Medical Sciences chronic hepatitis b; hepatitis b virus; hepatic fibrosis; fibroscan |
| title | A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy |
| title_full | A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy |
| title_fullStr | A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy |
| title_full_unstemmed | A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy |
| title_short | A study on outcome of hepatic fibrosis in chronic hepatitis B patients on anti-viral therapy |
| title_sort | study on outcome of hepatic fibrosis in chronic hepatitis b patients on anti viral therapy |
| topic | chronic hepatitis b; hepatitis b virus; hepatic fibrosis; fibroscan |
| url | https://www.nepjol.info/index.php/AJMS/article/view/59316 |
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