Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune Disease

Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune Disease

Glucocorticoids (GCs) are widely used immunosuppressive drugs for autoimmune diseases, although considerable gaps exist between current knowledge of the mechanisms of GCs and their conclusive immune-regulatory effects. Here we generated a single-cell transcriptional immune cell atlas based on predni...

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Bibliographic Details
Main Authors: He Li, Yuehan Gao, Lihui Xie, Rong Wang, Runping Duan, Zhaohuai Li, Binyao Chen, Lei Zhu, Xianggui Wang, Wenru Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
prednisone
glucocorticoids
autoimmune uveitis
single-cell RNA sequencing
CNS autoimmune diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.739605/full

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