Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country.
BACKGROUND: Statins reduce cardiovascular risks but increase the risk of new-onset diabetes (NOD). The aim of this study is to determine what effect, if any, statins have on the risk of NOD events in a population-based case-control study. An evaluation of the relationship between age and statin-expo...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3741277?pdf=render |
| _version_ | 1811280332158140416 |
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| author | Chih-Wei Chen Ting-Chang Chen Kuang-Yung Huang Pesus Chou Pin-Fan Chen Ching-Chih Lee |
| author_facet | Chih-Wei Chen Ting-Chang Chen Kuang-Yung Huang Pesus Chou Pin-Fan Chen Ching-Chih Lee |
| author_sort | Chih-Wei Chen |
| collection | DOAJ |
| description | BACKGROUND: Statins reduce cardiovascular risks but increase the risk of new-onset diabetes (NOD). The aim of this study is to determine what effect, if any, statins have on the risk of NOD events in a population-based case-control study. An evaluation of the relationship between age and statin-exposure on NOD risks was further examined in a female Asian population. METHOD: In a nationwide case-controlled study, the authors assessed 1065 female NOD patients and 10650 controls with matching ages, genders and physician visit dates. The impact of statin-exposure on NOD was examined through multiple logistic regression models. Subgroup analysis for exploring the risk of NOD and statin-exposure in different age groups was performed. RESULTS: Statin-exposure was statistically significantly associated with increased new-onset diabetes risks using multivariate analysis. Interaction effect between age and statin-exposure on NOD risk was noted. For atorvastatin, the risk of cDDDs>60 was highest among the 55-64 year-olds (adjusted odds ratio [OR], 8.0; 95% confidence interval [CI], 2.57-24.90). For rosuvastatin, the risk of cDDDs>60 was highest among the 40-54 year-olds (adjusted OR, 14.8; 95% CI, 2.27-96.15). For simvastatin, the risk of cDDDs>60 was highest among the 55-64 year-olds (adjusted OR, 15.8; 95% CI, 5.77-43.26). For pravastatin, the risk of cDDDs>60 was highest among the 55-64 year-olds (adjusted OR, 14.0; 95% CI, 1.56-125.18). CONCLUSIONS: This population-based study found that statin use is associated with an increased risk of NOD in women. The risk of statin-related NOD was more evident for women aged 40-64 years compared to women aged 65 or more, and was cumulative-dose dependent. The use of statins should always be determined by weighing the clinical benefits and potential risks for NOD, and the patients should be continuously monitored for adverse effects. |
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| id | doaj.art-0416ea800a8749e3966e3a6e5e97e4be |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T01:11:45Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-0416ea800a8749e3966e3a6e5e97e4be2022-12-22T03:09:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7181710.1371/journal.pone.0071817Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country.Chih-Wei ChenTing-Chang ChenKuang-Yung HuangPesus ChouPin-Fan ChenChing-Chih LeeBACKGROUND: Statins reduce cardiovascular risks but increase the risk of new-onset diabetes (NOD). The aim of this study is to determine what effect, if any, statins have on the risk of NOD events in a population-based case-control study. An evaluation of the relationship between age and statin-exposure on NOD risks was further examined in a female Asian population. METHOD: In a nationwide case-controlled study, the authors assessed 1065 female NOD patients and 10650 controls with matching ages, genders and physician visit dates. The impact of statin-exposure on NOD was examined through multiple logistic regression models. Subgroup analysis for exploring the risk of NOD and statin-exposure in different age groups was performed. RESULTS: Statin-exposure was statistically significantly associated with increased new-onset diabetes risks using multivariate analysis. Interaction effect between age and statin-exposure on NOD risk was noted. For atorvastatin, the risk of cDDDs>60 was highest among the 55-64 year-olds (adjusted odds ratio [OR], 8.0; 95% confidence interval [CI], 2.57-24.90). For rosuvastatin, the risk of cDDDs>60 was highest among the 40-54 year-olds (adjusted OR, 14.8; 95% CI, 2.27-96.15). For simvastatin, the risk of cDDDs>60 was highest among the 55-64 year-olds (adjusted OR, 15.8; 95% CI, 5.77-43.26). For pravastatin, the risk of cDDDs>60 was highest among the 55-64 year-olds (adjusted OR, 14.0; 95% CI, 1.56-125.18). CONCLUSIONS: This population-based study found that statin use is associated with an increased risk of NOD in women. The risk of statin-related NOD was more evident for women aged 40-64 years compared to women aged 65 or more, and was cumulative-dose dependent. The use of statins should always be determined by weighing the clinical benefits and potential risks for NOD, and the patients should be continuously monitored for adverse effects.http://europepmc.org/articles/PMC3741277?pdf=render |
| spellingShingle | Chih-Wei Chen Ting-Chang Chen Kuang-Yung Huang Pesus Chou Pin-Fan Chen Ching-Chih Lee Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country. PLoS ONE |
| title | Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country. |
| title_full | Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country. |
| title_fullStr | Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country. |
| title_full_unstemmed | Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country. |
| title_short | Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country. |
| title_sort | differential impact of statin on new onset diabetes in different age groups a population based case control study in women from an asian country |
| url | http://europepmc.org/articles/PMC3741277?pdf=render |
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