Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data
Background: Unlicensed and off-label (UL/OL) prescriptions have been associated with an increased risk of drug-related problems. Data of their prevalence at hospital discharge remain insufficient. We aimed to describe the prevalence of UL/OL drugs in outpatient prescriptions at discharge in children...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/12/2/208 |
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| author | Elham Jaberi Inesse Boussaha Xavier Dode Guillaume Grenet Behrouz Kassai Kim An Nguyen |
| author_facet | Elham Jaberi Inesse Boussaha Xavier Dode Guillaume Grenet Behrouz Kassai Kim An Nguyen |
| author_sort | Elham Jaberi |
| collection | DOAJ |
| description | Background: Unlicensed and off-label (UL/OL) prescriptions have been associated with an increased risk of drug-related problems. Data of their prevalence at hospital discharge remain insufficient. We aimed to describe the prevalence of UL/OL drugs in outpatient prescriptions at discharge in children. Methods: We conducted a retrospective study using the routinely collected health data of children at discharge from 2014 to 2016. The primary reference source for determining licensed labelling was the summaries of product characteristics (SPCs) in a French industry-independent formulary named Thériaque. We described the characteristics of UL/OL prescriptions at discharge and looked for predictors of UL/OL prescriptions. Results: We included 2536 prescriptions of 479 children. Licensed, OL, and UL prescriptions accounted for 58.6% (95% CI: 56.7–60.5), 39.2% (95% CI: 37.3–41.1), and 2.3% (95% CI: 1.7–2.9), respectively. A total of 323 (74%) children received at least one UL/OL drug. Among the licensed drugs, bronchodilators (8.8%) and analgesics (8.6%), and among the OL drugs, antibiotics (2.8%), were the most prescribed. The younger age of the children and higher number of drugs they received increased the probability of UL/OL prescriptions (unadjusted <i>p</i>-value of ≤0.05). Conclusion: The prevalence of UL/OL prescriptions is about 40% at discharge from a pediatric university hospital in France. |
| first_indexed | 2024-03-08T10:51:57Z |
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| id | doaj.art-0417af7b50124bdcb84e5ea47c3dfd91 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-08T10:51:57Z |
| publishDate | 2024-01-01 |
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| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-0417af7b50124bdcb84e5ea47c3dfd912024-01-26T16:46:08ZengMDPI AGHealthcare2227-90322024-01-0112220810.3390/healthcare12020208Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health DataElham Jaberi0Inesse Boussaha1Xavier Dode2Guillaume Grenet3Behrouz Kassai4Kim An Nguyen5UMR CNRS 5558, Laboratoire de Biométrie et Biologie Humaine, Équipe Évaluation et Modélisation des Effets Thérapeutiques, rue Guillaume-Paradin, BP8071, CEDEX 08, F-69376 Lyon, FranceDepartment of Clinical Epidemiology, Hospices Civils de Lyon, CIC 1407 de Lyon, Inserm, CHU-Lyon, F-69677 Bron, FrancePharmacy Department, Hospices Civils de Lyon University Hospital, F-69002 Lyon, FranceUMR CNRS 5558, Laboratoire de Biométrie et Biologie Humaine, Équipe Évaluation et Modélisation des Effets Thérapeutiques, rue Guillaume-Paradin, BP8071, CEDEX 08, F-69376 Lyon, FranceUMR CNRS 5558, Laboratoire de Biométrie et Biologie Humaine, Équipe Évaluation et Modélisation des Effets Thérapeutiques, rue Guillaume-Paradin, BP8071, CEDEX 08, F-69376 Lyon, FranceUMR CNRS 5558, Laboratoire de Biométrie et Biologie Humaine, Équipe Évaluation et Modélisation des Effets Thérapeutiques, rue Guillaume-Paradin, BP8071, CEDEX 08, F-69376 Lyon, FranceBackground: Unlicensed and off-label (UL/OL) prescriptions have been associated with an increased risk of drug-related problems. Data of their prevalence at hospital discharge remain insufficient. We aimed to describe the prevalence of UL/OL drugs in outpatient prescriptions at discharge in children. Methods: We conducted a retrospective study using the routinely collected health data of children at discharge from 2014 to 2016. The primary reference source for determining licensed labelling was the summaries of product characteristics (SPCs) in a French industry-independent formulary named Thériaque. We described the characteristics of UL/OL prescriptions at discharge and looked for predictors of UL/OL prescriptions. Results: We included 2536 prescriptions of 479 children. Licensed, OL, and UL prescriptions accounted for 58.6% (95% CI: 56.7–60.5), 39.2% (95% CI: 37.3–41.1), and 2.3% (95% CI: 1.7–2.9), respectively. A total of 323 (74%) children received at least one UL/OL drug. Among the licensed drugs, bronchodilators (8.8%) and analgesics (8.6%), and among the OL drugs, antibiotics (2.8%), were the most prescribed. The younger age of the children and higher number of drugs they received increased the probability of UL/OL prescriptions (unadjusted <i>p</i>-value of ≤0.05). Conclusion: The prevalence of UL/OL prescriptions is about 40% at discharge from a pediatric university hospital in France.https://www.mdpi.com/2227-9032/12/2/208childrendrug prescriptiondischargeunlicensedoff-label |
| spellingShingle | Elham Jaberi Inesse Boussaha Xavier Dode Guillaume Grenet Behrouz Kassai Kim An Nguyen Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data Healthcare children drug prescription discharge unlicensed off-label |
| title | Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data |
| title_full | Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data |
| title_fullStr | Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data |
| title_full_unstemmed | Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data |
| title_short | Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data |
| title_sort | unlicensed off label drug prescriptions at hospital discharge in children an observational study using routinely collected health data |
| topic | children drug prescription discharge unlicensed off-label |
| url | https://www.mdpi.com/2227-9032/12/2/208 |
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