Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature
Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/276 |
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| author | Gianluca Serafini Matteo Pardini Fiammetta Monacelli Beatrice Orso Nicola Girtler Andrea Brugnolo Mario Amore Flavio Nobili Disease Management Team on Dementia of the IRCCS Ospedale Policlinico San Martino |
| author_facet | Gianluca Serafini Matteo Pardini Fiammetta Monacelli Beatrice Orso Nicola Girtler Andrea Brugnolo Mario Amore Flavio Nobili Disease Management Team on Dementia of the IRCCS Ospedale Policlinico San Martino |
| author_sort | Gianluca Serafini |
| collection | DOAJ |
| description | Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points. |
| first_indexed | 2024-03-09T00:35:07Z |
| format | Article |
| id | doaj.art-04183688ae3947e5a6327c1fa6b4cc5a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T00:35:07Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-04183688ae3947e5a6327c1fa6b4cc5a2023-12-11T18:10:12ZengMDPI AGBrain Sciences2076-34252021-02-0111227610.3390/brainsci11020276Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current LiteratureGianluca Serafini0Matteo Pardini1Fiammetta Monacelli2Beatrice Orso3Nicola Girtler4Andrea Brugnolo5Mario Amore6Flavio Nobili7Disease Management Team on Dementia of the IRCCS Ospedale Policlinico San Martino8Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, 16132 Genoa, ItalyIRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyIRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Neurology, University of Genoa, 16132 Genoa, ItalyIRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, 16132 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, 16132 Genoa, ItalyIRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, 16132 Genoa, ItalyBipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points.https://www.mdpi.com/2076-3425/11/2/276bipolar disorderillness trajectoryneuroprogressionillness courseillness outcome |
| spellingShingle | Gianluca Serafini Matteo Pardini Fiammetta Monacelli Beatrice Orso Nicola Girtler Andrea Brugnolo Mario Amore Flavio Nobili Disease Management Team on Dementia of the IRCCS Ospedale Policlinico San Martino Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature Brain Sciences bipolar disorder illness trajectory neuroprogression illness course illness outcome |
| title | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
| title_full | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
| title_fullStr | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
| title_full_unstemmed | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
| title_short | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
| title_sort | neuroprogression as an illness trajectory in bipolar disorder a selective review of the current literature |
| topic | bipolar disorder illness trajectory neuroprogression illness course illness outcome |
| url | https://www.mdpi.com/2076-3425/11/2/276 |
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